Glutamate receptor ionotropic, NMDA 2A

BE0000760ProteinHumansGRIN2A

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). It is acted on by 17 drugs in DrugBank.

Gene name
GRIN2A
UniProtKB entry
Q12879Swiss-Prot
Cellular location
Cell projection, dendritic spine
Residues / weight
1,464 residues · 165,281 Da
Also known as
GluN2A · Glutamate [NMDA] receptor subunit epsilon-1 · hNR2A · N-methyl D-aspartate receptor subtype 2A · NMDAR2A

Resolves to

Protein
UniProtQ12879UniProt nameNMDE1_HUMAN
Gene
HGNCHGNC:4585NCBI Gene2903GenBank558749GeneCardsGRIN2A
Pharmacology
IUPHAR/GtoPdb456KEGGhsa:2903
Structure
PDB3NFLPDB5H8FPDB5H8H
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor ionotropic, NMDA 2A, how selective are they, and which programs against it are still in active trials?

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