DB00514ApprovedInvestigationalSmall moleculeAntitussive AgentsSigma-1 AgonistUncompetitive N-methyl-D-aspartate Receptor Antagonist
Dextromethorphan is an NMDA receptor antagonist used to treat cases of dry cough. Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse.
- Mechanism
- Curator reviewed · 3 references
Dextromethorphan is a low-affinity uncompetitive NMDA antagonist and sigma-1 receptor agonist. It is also an antagonist of α3/β4 nicotinic receptors. However, the mechanism by which dextromethorphan's receptor agonism and antagonism translate to a clinical effect is not well understood.
- Primary indication
- Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold.Curator reviewed · 75 structured indications
- Formula / weight
- C18H25NO · 271.404 g/mol (avg)
- First approval
- Canada, 1996 · United States, 1985
- Also known as
- D-methorphan · delta-Methorphan · Dextromethorphan polistirex
- Code names
- BA 2666
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
MKXZASYAUGDDCJ-NJAFHUGGSA-NSMILES[H][C@]12CCCC[C@]11CCN(C)[C@H]2CC2=C1C=C(OC)C=C2What you can answer from here — as of September 25, 2026
17Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Dextromethorphan, and which of those have an active Phase 3 trial?
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