DNA topoisomerase 4 subunit A

BE0000798ProteinEscherichia coli (strain K12)parC

Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed:9334322). It is acted on by 12 drugs in DrugBank.

Gene name
parC
UniProtKB entry
P0AFI2Swiss-Prot
Cellular location
Cell membrane
Residues / weight
752 residues · 83,830 Da
Also known as
5.6.2.2 · 5.99.1.3 · Topoisomerase IV subunit A

Resolves to

Protein
UniProtP0AFI2UniProt namePARC_ECOLI
Gene
NCBI Gene947499GenBank147106
Pharmacology
KEGGecj:JW2987
Structure
PDB1ZVTPDB1ZVUPDB4MN4
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA topoisomerase 4 subunit A, how selective are they, and which programs against it are still in active trials?

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