NPC1-like intracellular cholesterol transporter 1

BE0000802ProteinHumansNPC1L1

Plays a major role in cholesterol homeostasis (PubMed:22095670). It is acted on by 5 drugs in DrugBank.

Gene name
NPC1L1
UniProtKB entry
Q9UHC9Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,359 residues · 148,727 Da
Also known as
Niemann-Pick C1-like protein 1 · NPC1L1

Resolves to

Protein
UniProtQ9UHC9UniProt nameNPCL1_HUMAN
Gene
HGNCHGNC:7898NCBI Gene29881GenBank6643036GeneCardsNPC1L1
Pharmacology
IUPHAR/GtoPdb2629KEGGhsa:29881
Structure
PDB3QNTPDB7DF8PDB7DFW
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NPC1-like intracellular cholesterol transporter 1, how selective are they, and which programs against it are still in active trials?

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