Glutathione peroxidase 1

BE0000816ProteinHumansGPX1

Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). It is acted on by 9 drugs in DrugBank.

Gene name
GPX1
UniProtKB entry
P07203Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
203 residues · 22,088 Da
Also known as
1.11.1.9 · Cellular glutathione peroxidase · GPx-1 · GSHPx-1 · Phospholipid-hydroperoxide glutathione peroxidase GPX1

Resolves to

Protein
UniProtP07203UniProt nameGPX1_HUMAN
Gene
HGNCHGNC:4553NCBI Gene2876GenBank577777GeneCardsGPX1
Pharmacology
KEGGhsa:2876
Structure
PDB2F8A
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione peroxidase 1, how selective are they, and which programs against it are still in active trials?

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