Identification
- Summary
Hydrogen peroxide is a compound used as a disinfectant and sterilizer.
- Brand Names
- Eskata, Orajel Mouth Sore Rinse
- Generic Name
- Hydrogen peroxide
- DrugBank Accession Number
- DB11091
- Background
Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition. Hydrogen peroxide is formed in the body of mammals during reduction of oxygen either directly in a two-electron transfer reaction 4. As a natural product of metabolism, it readily undergoes decomposition by catalase in normal cells 4.
Due to its potent and broad-spectrum antimicrobial actions, hydrogen peroxide is used in both liquid and gas form for preservative, disinfection and sterilization applications as an oxidative biocide 1. It is used in industrial and cosmetic applications as a bleaching agent. Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA 4; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg whites, and dried egg yolks.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Hydrogen peroxide (DB11091)
- Weight
- Average: 34.0147
Monoisotopic: 34.005479308 - Chemical Formula
- H2O2
- Synonyms
- Hydrogen peroxide
- External IDs
- A-101
- NSC-19892
Pharmacology
- Indication
Indicated to be used as a disinfectant and sterilizer.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Hydrogen peroxide exhibits antimicrobial properties against most forms of microorganisms, including dormant forms with known high resistance profiles, such as bacterial spores and protozoal cysts. It acts as an oxidative biocide to generate free radical species to induce DNA, protein and membrane lipid damage via oxidation.
- Mechanism of action
The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids in vivo 2. The oxidizing radical as the ferryl radical induces DNA oxidation 2.
- Absorption
It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue 4.
- Volume of distribution
Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney 4.
- Protein binding
Not Available
- Metabolism
Hydrogen peroxide is reduced by glutathione peroxidase, which is an endogenous enzyme in human tissue. It is rapidly decomposed to oxygen and water when in contact with catalase, an enzyme found in blood and most tissues 4.
Hover over products below to view reaction partners
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Oral LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig. LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours MSDS.
Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans. Inhalation of highly concentrated vapours causes extreme irritation of nose and throat 4.
Hydrogen peroxide has no known carcinogenic potential. It was shown to be mutagenic to bacteria (Salmonella typhimurium) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli 4. It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro 4.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetylcysteine The therapeutic efficacy of Acetylcysteine can be decreased when used in combination with Hydrogen peroxide. Albutrepenonacog alfa Hydrogen peroxide may increase the thrombogenic activities of Albutrepenonacog alfa. Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Hydrogen peroxide. Alteplase The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Alteplase. Aminocaproic acid Aminocaproic acid may increase the thrombogenic activities of Hydrogen peroxide. Andexanet alfa Hydrogen peroxide may increase the thrombogenic activities of Andexanet alfa. Anistreplase The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Anistreplase. Anti-inhibitor coagulant complex Hydrogen peroxide may increase the thrombogenic activities of Anti-inhibitor coagulant complex. Antihemophilic factor (recombinant), PEGylated Hydrogen peroxide may increase the thrombogenic activities of Antihemophilic factor (recombinant), PEGylated. Antihemophilic factor human Hydrogen peroxide may increase the thrombogenic activities of Antihemophilic factor human. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Eskata Solution 40 mg/100mg Topical Aclaris Therapeutics, Inc. 2017-12-14 Not applicable US 
Eskata Solution 40 mg/100mg Topical Aclaris Therapeutics, Inc. 2017-12-14 Not applicable US Perioselect Hydrogen Peroxide Solution 1.7% Liquid 1.7 % Dental Sultan Healthcare 1992-12-31 1996-09-06 Canada 
Preop Rinse Liquid 3.8 mL/100mL Oral Everbrands, Inc. dba EverPure, Inc. 2020-12-30 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 100 toothpast e Afternoon Gel, dentifrice 2.14 g/100g Oral MGRU 2020-12-01 Not applicable US 16oz Hydorgen Peroxide Liquid 3 mL/1 Topical Ningbo Liyuan Daily Chemical Products Co., Ltd. 2017-01-04 Not applicable US 16oz Hydrogen Peroxide Liquid 3 mL/3mL Oral; Topical Collective Science Integration 2020-09-24 Not applicable US 3 Hydrogen Peroxide Liquid 30 mg/1mL Topical Jell Pharmaceuticals Pvt Ltd. 2021-01-10 Not applicable US 3 percent Hydrogen Peroxide Gel 3 mL/100mL Topical Solugen Blending, LLC 2020-10-12 Not applicable US 3% Hydrogen Peroxide Liquid 3 mL/100mL Topical Streamline Polymers LLC 2020-09-25 Not applicable US 3% Hydrogen Peroxide Liquid 30 mg/1mL Topical MBS Medical Technologies, Inc. 2020-09-15 Not applicable US 3% Hydrogen Peroxide Well at Walgreens Spray 3 g/100mL Topical Walgreens 2014-02-15 2018-03-08 US 32oz Hydrogen Peroxide Liquid 3 mL/3mL Oral; Topical Collective Science Integration 2020-09-24 Not applicable US American Red Cross 3 Hydrogen Peroxide Liquid 30 mg/1mL Topical My Imports USA LLC 2021-01-10 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4234 First Aid Kit Hydrogen peroxide (3 mL/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) Kit Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable US Antiseptic Mouth Sore Hydrogen peroxide (15 mg/1mL) + Menthol (1 mg/1mL) Rinse Periodontal CVS PHARMACY 2021-06-18 Not applicable US BANEN Rinse-free Hand Sanitizer (II) Hydrogen peroxide (0.5 mL/500mL) + Ethanol (400 mL/500mL) Liquid Extracorporeal LIONSER Medical Disinfectant(Hangzhou) Co., Ltd. 2020-03-24 Not applicable US Defense AG Disinfectant Hydrogen peroxide (0.125 mL/100mL) + Ethanol (80 mL/100mL) Spray Topical Nexderma 2020-11-09 Not applicable US Defense AG Disinfectant Hydrogen peroxide (0.125 mL/100mL) + Isopropyl alcohol (75 mL/100mL) Spray Topical Nexderma 2020-11-09 Not applicable US Diabek-100 Hydrogen peroxide (0.000005 mL/1mL) + Sodium hypochlorite (0.000005 mg/1mL) + Hypochlorous acid (0.00002 mg/1mL) Solution Topical JOAQUIN ARMANDO CARDENAS URQUIDEZ 2021-03-11 Not applicable US Diabek-100 Hydrogen peroxide (0.000005 mL/1mL) + Sodium hypochlorite (0.000004 mg/1mL) + Hypochlorous acid (0.000015 mg/1mL) Solution Buccal JOAQUIN ARMANDO CARDENAS URQUIDEZ 2021-03-02 Not applicable US Diabek-100 Hydrogen peroxide (0.000005 g/1g) + Sodium hypochlorite (0.000005 g/1g) + Hypochlorous acid (0.00002 g/1g) Gel Topical JOAQUIN ARMANDO CARDENAS URQUIDEZ 2021-03-02 Not applicable US Dio Whitening Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Dio 2015-01-22 Not applicable US Dr.EL TOOTH WHITE TOOTH Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Dr. EL CO., LTD. 2019-08-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 100 toothpast e Afternoon Hydrogen peroxide (2.14 g/100g) Gel, dentifrice Oral MGRU 2020-12-01 Not applicable US 4234 First Aid Kit Hydrogen peroxide (3 mL/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) Kit Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable US Dio Whitening Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Dio 2015-01-22 Not applicable US Dr.EL TOOTH WHITE TOOTH Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Dr. EL CO., LTD. 2019-08-01 Not applicable US Dr.LORD Propol Whitening Tooth Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7.0 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Oral Red 99 2022-03-01 Not applicable US Dr.pauhls Natural Tone Up Tooth Hydrogen peroxide (1.81 g/85g) + Silicon dioxide (5.95 g/85g) + alpha-Tocopherol acetate (0.17 g/85g) Paste, dentifrice Topical Curescript 2021-02-01 Not applicable US Eco Whitening Hydrogen peroxide (8.57 g/100mL) Gel Dental Jn Pharm 2014-02-08 Not applicable US KUNDAL Pure Refreshing Whitening Tooth (Spearmint) Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) Paste Dental THESKINFACTORY Co., Ltd. 2020-09-01 Not applicable US Luzen Whitening Gel Hydrogen peroxide (2.8 g/100g) Gel Topical Biostech Co., Ltd. 2020-12-23 Not applicable US Mastikis Mastic 24K Whitening Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Mastic Korea.Co.Ltd 2021-01-28 Not applicable US
Categories
- ATC Codes
- D08AX01 — Hydrogen peroxide
- D08AX — Other antiseptics and disinfectants
- D08A — ANTISEPTICS AND DISINFECTANTS
- D08 — ANTISEPTICS AND DISINFECTANTS
- D — DERMATOLOGICALS
- D11AX — Other dermatologicals
- D11A — OTHER DERMATOLOGICAL PREPARATIONS
- D11 — OTHER DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- Drug Categories
- Alimentary Tract and Metabolism
- Anions
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antifibrinolytic Agents
- Antiinfectives and Antiseptics for Local Oral Treatment
- Antiseptics and Disinfectants
- Compounds used in a research, industrial, or household setting
- Dermatologicals
- Electrolytes
- Free Radicals
- Ions
- Noxae
- Otologicals
- Oxidants
- Oxides
- Oxygen Compounds
- Peroxides
- Reactive Oxygen Species
- Sensory Organs
- Stomatological Preparations
- Toxic Actions
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Homogeneous other non-metal compounds
- Sub Class
- Not Available
- Direct Parent
- Homogeneous other non-metal compounds
- Alternative Parents
- Not Available
- Substituents
- Homogeneous other non metal
- Molecular Framework
- Not Available
- External Descriptors
- reactive oxygen species, inorganic peroxide (CHEBI:16240) / a small molecule (HYDROGEN-PEROXIDE)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- BBX060AN9V
- CAS number
- 7722-84-1
- InChI Key
- MHAJPDPJQMAIIY-UHFFFAOYSA-N
- InChI
- InChI=1S/H2O2/c1-2/h1-2H
- IUPAC Name
- peroxol
- SMILES
- OO
References
- General References
- Finnegan M, Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms. J Antimicrob Chemother. 2010 Oct;65(10):2108-15. doi: 10.1093/jac/dkq308. Epub 2010 Aug 16. [Article]
- Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action. J Antimicrob Chemother. 2012 Jul;67(7):1589-96. doi: 10.1093/jac/dks129. Epub 2012 Apr 24. [Article]
- HYDROGEN PEROXIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- Chemical Summary for Hydrogen Peroxide - SSWM [Link]
- FDA Approved Drug Products: Eskata Hydrogen Peroxide Topical Solution (Discontinued) [Link]
- External Links
- Human Metabolome Database
- HMDB0003125
- KEGG Compound
- C00027
- PubChem Compound
- 784
- PubChem Substance
- 347827892
- ChemSpider
- 763
- 5499
- ChEBI
- 16240
- ChEMBL
- CHEMBL71595
- PDBe Ligand
- PEO
- Wikipedia
- Hydrogen_peroxide
- PDB Entries
- 1ao2 / 1ao4 / 1asp / 1d6z / 1g5l / 1ggf / 1gj2 / 1h57 / 1h5f / 1h5g … show 81 more
- MSDS
- Download (53.8 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Coronavirus Disease 2019 (COVID‑19) / Infections, Coronavirus / Mouthwashes / Polymerase Chain Reaction / Saliva / Viral Load 1 4 Completed Treatment Seborrheic Keratosis (SK) 1 4 Completed Treatment Sensitivity / Tooth Whitening 1 4 Completed Treatment Unilateral Knee Arthroplasty 1 4 Recruiting Prevention Coronavirus Disease 2019 (COVID‑19) 1 4 Terminated Treatment Chronic Periodontitis (Disorder) 1 4 Unknown Status Prevention Coronavirus Disease 2019 (COVID‑19) 1 3 Completed Treatment Seborrheic Keratosis (SK) 3 3 Completed Treatment Sensitivity, Tooth 1 3 Completed Treatment Tooth Whitening 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel, dentifrice Oral 2.14 g/100g Liquid Topical 3 mL/1 Liquid Oral; Topical 3 mL/3mL Gel Topical 3 mL/100mL Spray Topical 3 g/100mL Kit Respiratory (inhalation); Topical Solution Topical 6 g Solution Topical 7.2 g Solution Topical 6.01 g Spray Topical 30 mL/1000mL Rinse Periodontal Mouthwash Oral 150 mg/100L Spray Topical 3.0 mL/100mL Liquid Extracorporeal Spray Topical 1 mL/100mL Liquid Topical 0.085 mL/70mL Liquid Topical 2.65 mL/100mL Cream Topical Spray Topical Rinse Topical 15 mg/1mL Paste, dentifrice Dental Solution Topical 3.6 g Liquid Topical 5 mg/100mL Liquid Topical 3 mL/100mL Liquid Topical 3 g/100mL Liquid Topical 4 mL/100mL Liquid Topical 13.5 mL/450mL Cloth Topical Paste, dentifrice Topical Gel Dental 8.57 g/100mL Solution Topical 40 mg/100mg Liquid Oral 1.5 g/100mL Spray, metered Topical 3.54 mL/119mL Aerosol, spray Topical Cream Topical 1.5 % Liquid Dental; Oral; Topical 0.03 mL/100mL Liquid Oral 0.015 mg/1mL Liquid Oral; Topical 2.65 mL/100mL Liquid Oral; Topical 3 mL/100mL Liquid Topical .3 kg/100L Liquid Topical 0.03 L/0.03L Liquid Topical 0.3 mL/1mL Liquid Topical 3 mg/1mL Liquid Topical 30 mL/1L Liquid Topical 50 mL/100mL Liquid Topical 8.57 g/100mL Lotion Topical 3 kg/100L Solution Oral; Topical 2.65 mL/100mL Solution Oral; Topical 3 mL/100mL Solution Topical .3 kg/100L Solution Topical 0.03 mL/1mL Solution Topical 3 mL/100mL Solution Topical 3 mg/100mL Solution Topical 30 mg/1mL Spray Topical 3.57 mL/118mL Spray Topical 30 mg/1mL Spray Topical 30 mL/1L Liquid Topical 6 g / 100 mL Swab Topical 0.03 mL/1 Liquid Topical 6 mL / 100 mL Liquid Topical 6 % Liquid Oral 1.5 1/1001 Liquid Topical 3 % Solution 20 ml/100ml Solution Topical 3 g / 100 mL Solution Topical 3 % Solution Topical Kit Oral Kit Oral 0.015 mg/1mL Paste Dental Gel Topical 2.8 g/100g Liquid Topical 30 mg/1mL Liquid Topical Spray Topical 43.275 g/1L Mouthwash Dental 15 mg/1mL Liquid Oral 15 mg/1mL Cloth Topical 1.22 mg/100mg Spray Topical 0.48 g/40mL Liquid Extracorporeal 15 mg/500mL Liquid Oral Liquid Oral 0.015 mL/1mL Mouthwash Oral 1.5 % Solution Buccal Rinse Oral 0.03 mL/20mL Solution Oral 2.94 mL/2.94mL Spray Oral 2.94 mL/2.94mL Solution Oral 1.5 mL/1.5mL Spray Oral 1.5 mL/1.5mL Liquid Buccal 15 mg/1mL Gel Dental; Periodontal 17 g/100mL Gel Dental; Periodontal 1.7 g/100g Gel Topical 17 mg/1g Gel Dental 17 mg/1g Liquid Dental 1.7 % Mouthwash Buccal 15 mg/1mL Rinse Oral 1.5 mL/100mL Rinse Buccal 15 mg/1mL Cloth Topical 30 mg/1mL Liquid Topical 3 g/100g Liquid Topical 3 mL/1mL Swab Topical 30 mg/1mL Gel, dentifrice Dental 35 mL/100mL Rinse Oral 26.5 mg/1mL Liquid Oral 3.8 mL/100mL Liquid Topical 0.03 mL/1mL Spray Topical 0.03 mL/1mL Liquid Topical 1.5 g/100mL Liquid Topical 14.19 mL/473mL Gel Oral 3 g/100g Kit Dental Kit; mouthwash Buccal 15 mg/1mL Kit Buccal Gel Topical Rinse Oral Kit Topical Liquid Topical 5.845 g/100mL Concentrate Topical 18 mL/100mL Cloth Topical 3 mL/100mL Swab Buccal 15 mg/1mL Cloth Topical 0.03 mL/1mL Spray Topical 3 mL/100mL Mouthwash Topical 15 mg/1mL Mouthwash Topical 150 mg/10mL Mouthwash Topical 1588 mg/1mL Kit Buccal 15 mg/1mL Solution Buccal 15 mg/1mL Rinse Dental 0.15 mL/100mL Paste, dentifrice Dental 2.14 g/100g Kit Buccal 15 [iU]/1mL Cloth Topical 0.6684 g/44.56g Paste, dentifrice Oral Paste, dentifrice Oral 1.92 g/90g Liquid Oral 1.5 % Solution Topical Liquid Oral 0.42 g/15g Liquid Oral 2.8 g/100g Spray, metered Topical 3.57 mL/119mL Cloth Topical 3 g/1001 - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US7381427 No 2008-06-03 2022-06-08 US US9675639 No 2017-06-13 2035-07-04 US US9980983 No 2018-05-29 2035-04-21 US US10098910 No 2018-10-16 2035-04-21 US US10493103 No 2019-12-03 2035-04-21 US US10729720 No 2020-08-04 2035-04-21 US
Properties
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) -33 MSDS boiling point (°C) 108 MSDS water solubility Soluble in cold water MSDS - Predicted Properties
Property Value Source logP -0.45 Chemaxon pKa (Strongest Acidic) 11.52 Chemaxon pKa (Strongest Basic) -4.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 40.46 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 5.13 m3·mol-1 Chemaxon Polarizability 2.29 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9000000000-50a90bb1548c24e83fbe Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9000000000-50a90bb1548c24e83fbe Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9000000000-50a90bb1548c24e83fbe Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-9000000000-a9a93dd42f2cfa0b34c4 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-9000000000-a9a93dd42f2cfa0b34c4 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Sh3 domain binding
- Specific Function
- Protects the hemoglobin in erythrocytes from oxidative breakdown.
- Gene Name
- GPX1
- Uniprot ID
- P07203
- Uniprot Name
- Glutathione peroxidase 1
- Molecular Weight
- 22087.94 Da
References
- Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN: Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9. [Article]
- HYDROGEN PEROXIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- Chemical Summary for Hydrogen Peroxide - SSWM [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Receptor binding
- Specific Function
- Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia c...
- Gene Name
- CAT
- Uniprot ID
- P04040
- Uniprot Name
- Catalase
- Molecular Weight
- 59755.82 Da
References
- Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN: Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9. [Article]
- HYDROGEN PEROXIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- Chemical Summary for Hydrogen Peroxide - SSWM [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- ALPPL2
- Uniprot ID
- P10696
- Uniprot Name
- Alkaline phosphatase, placental-like
- Molecular Weight
- 57376.515 Da
References
- Finnegan M, Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms. J Antimicrob Chemother. 2010 Oct;65(10):2108-15. doi: 10.1093/jac/dkq308. Epub 2010 Aug 16. [Article]
Drug created at December 03, 2015 16:51 / Updated at February 21, 2021 18:52