Glutaminase kidney isoform, mitochondrial

BE0000825ProteinHumansGLS

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. It is acted on by 7 drugs in DrugBank.

Gene name
GLS
UniProtKB entry
O94925Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
669 residues · 73,461 Da
Also known as
3.5.1.2 · GLS · GLS1 · K-glutaminase · KIAA0838

Resolves to

Protein
UniProtO94925UniProt nameGLSK_HUMAN
Gene
HGNCHGNC:4331NCBI Gene2744GenBank5690372GeneCardsGLS
Pharmacology
IUPHAR/GtoPdb2891KEGGhsa:2744
Structure
PDB3CZDPDB3UNWPDB3UO9
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutaminase kidney isoform, mitochondrial, how selective are they, and which programs against it are still in active trials?

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