T-lymphocyte activation antigen CD86

BE0000846ProteinHumansCD86

Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:12196291, PubMed:7694363). It is acted on by 4 drugs in DrugBank.

Gene name
CD86
UniProtKB entry
P42081Swiss-Prot
Cellular location
Cell membrane
Residues / weight
329 residues · 37,682 Da
Also known as
Activation B7-2 antigen · B70 · BU63 · CD28LG2 · CTLA-4 counter-receptor B7.2

Resolves to

Protein
UniProtP42081UniProt nameCD86_HUMAN
Gene
HGNCHGNC:1705NCBI Gene942GenBank439839GeneCardsCD86
Pharmacology
IUPHAR/GtoPdb2745KEGGhsa:942
Structure
PDB1I85PDB1NCNPDB5YXK
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
11Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
27+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on T-lymphocyte activation antigen CD86, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In