Cytotoxic T-lymphocyte protein 4

BE0000887ProteinHumansCTLA4

Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). It is acted on by 16 drugs in DrugBank.

Gene name
CTLA4
UniProtKB entry
P16410Swiss-Prot
Cellular location
Cell membrane
Residues / weight
223 residues · 24,656 Da
Also known as
CD152 · CTLA-4 · Cytotoxic T-lymphocyte-associated antigen 4

Resolves to

Protein
UniProtP16410UniProt nameCTLA4_HUMAN
Gene
HGNCHGNC:2505NCBI Gene1493GenBank17646228GeneCardsCTLA4
Pharmacology
IUPHAR/GtoPdb2743KEGGhsa:1493
Structure
PDB1AH1PDB1H6EPDB1I85
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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148Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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84+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytotoxic T-lymphocyte protein 4, how selective are they, and which programs against it are still in active trials?

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