Potassium voltage-gated channel subfamily KQT member 2

BE0000897ProteinHumansKCNQ2

Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). It is acted on by 7 drugs in DrugBank.

Gene name
KCNQ2
UniProtKB entry
O43526Swiss-Prot
Cellular location
Cell membrane
Residues / weight
872 residues · 95,847 Da
Also known as
KQT-like 2 · Neuroblastoma-specific potassium channel subunit alpha KvLQT2 · Voltage-gated potassium channel subunit Kv7.2

Resolves to

Protein
UniProtO43526UniProt nameKCNQ2_HUMAN
Gene
HGNCHGNC:6296NCBI Gene3785GenBank1841342GeneCardsKCNQ2
Pharmacology
IUPHAR/GtoPdb561KEGGhsa:3785
Structure
PDB5J03PDB6FEGPDB6FEH
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium voltage-gated channel subfamily KQT member 2, how selective are they, and which programs against it are still in active trials?

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