Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities.
- Mechanism
- Curator reviewed
The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease.
- Primary indication
- For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss.Curator reviewed · 12 structured indications
- Formula / weight
- C14H11Cl2NO2 · 296.149 g/mol (avg)
- First approval
- United States, 1986
- Also known as
- Meclofenamate
- Code names
- CI-583 · Cl 583 · INF-4668
Resolves to
SBDNJUWAMKYJOX-UHFFFAOYSA-NSMILESCC1=C(Cl)C(NC2=CC=CC=C2C(O)=O)=C(Cl)C=C1What you can answer from here — as of September 12, 2026
Which drugs share a target with Meclofenamic acid, and which of those have an active Phase 3 trial?
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