Glycogen phosphorylase, muscle form

BE0000916ProteinHumansPYGM

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. It is acted on by 56 drugs in DrugBank.

Gene name
PYGM
UniProtKB entry
P11217Swiss-Prot
Residues / weight
842 residues · 97,091 Da
Also known as
2.4.1.1 · Myophosphorylase

Resolves to

Protein
UniProtP11217UniProt namePYGM_HUMAN
Gene
HGNCHGNC:9726NCBI Gene5837GenBank190784GeneCardsPYGM
Pharmacology
KEGGhsa:5837
Structure
PDB1Z8D
Drugs

What you can answer from here — as of September 07, 2019

56DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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100+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycogen phosphorylase, muscle form, how selective are they, and which programs against it are still in active trials?

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