Mitogen-activated protein kinase 1

BE0000923ProteinHumansMAPK1

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 26 drugs in DrugBank.

Gene name
MAPK1
UniProtKB entry
P28482Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, spindle
Residues / weight
360 residues · 41,389 Da
Also known as
2.7.11.24 · ERK-2 · ERK2 · ERT1 · Extracellular signal-regulated kinase 2

Resolves to

Protein
UniProtP28482UniProt nameMK01_HUMAN
Gene
HGNCHGNC:6871NCBI Gene5594GenBank182191GeneCardsMAPK1
Pharmacology
IUPHAR/GtoPdb1495KEGGhsa:5594
Structure
PDB1PMEPDB1TVOPDB1WZY
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
11Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
30GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
120+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Mitogen-activated protein kinase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In