Dihydropyrimidine dehydrogenase [NADP(+)]

BE0000960ProteinHumansDPYD

Catalyzes the reduction of uracil and thymine in the initial step of reductive pyrimidine catabolism, a pathway that yields beta-alanine from uracil and beta-aminoisobutyrate from thymine (PubMed:1512248). It is acted on by 12 drugs in DrugBank.

Gene name
DPYD
UniProtKB entry
Q12882Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,025 residues · 111,400 Da
Also known as
1.3.1.2 · DHPDHase · Dihydrothymine dehydrogenase · Dihydrouracil dehydrogenase · DPD

Resolves to

Protein
UniProtQ12882UniProt nameDPYD_HUMAN
Gene
HGNCHGNC:3012NCBI Gene1806GenBank558305GeneCardsDPYD
Pharmacology
KEGGhsa:1806
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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22Clinical trialsTrials of drugs acting on it, by phase and status
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydropyrimidine dehydrogenase [NADP(+)], how selective are they, and which programs against it are still in active trials?

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