Metabotropic glutamate receptor 2

BE0000974ProteinHumansGRM2

Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). It is acted on by 12 drugs in DrugBank.

Gene name
GRM2
UniProtKB entry
Q14416Swiss-Prot
Cellular location
Cell membrane
Residues / weight
872 residues · 95,567 Da
Also known as
GPRC1B · MGLUR2

Resolves to

Protein
UniProtQ14416UniProt nameGRM2_HUMAN
Gene
HGNCHGNC:4594NCBI Gene2912GenBank999416GeneCardsGRM2
Pharmacology
IUPHAR/GtoPdb290KEGGhsa:2912
Structure
PDB4XAQPDB4XASPDB5CNI
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Metabotropic glutamate receptor 2, and which indications are they being tested in?

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