Angiotensin-converting enzyme 2

BE0000982ProteinHumansACE2

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). It is acted on by 12 drugs in DrugBank.

Gene name
ACE2
UniProtKB entry
Q9BYF1Swiss-Prot
Cellular location
Secreted
Residues / weight
805 residues · 92,462 Da
Also known as
3.4.17.23 · ACE-related carboxypeptidase · ACEH · Angiotensin-converting enzyme homolog · Angiotensin-converting enzyme-related carboxypeptidase

Resolves to

Protein
UniProtQ9BYF1UniProt nameACE2_HUMAN
Gene
HGNCHGNC:13557NCBI Gene59272GenBank9802433GeneCardsACE2
Pharmacology
IUPHAR/GtoPdb1614KEGGhsa:59272
Structure
PDB1R42PDB1R4LPDB28KD
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Angiotensin-converting enzyme 2, how selective are they, and which programs against it are still in active trials?

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