Rho-associated protein kinase 1

BE0001016ProteinHumansROCK1

Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). It is acted on by 13 drugs in DrugBank.

Gene name
ROCK1
UniProtKB entry
Q13464Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,354 residues · 158,174 Da
Also known as
2.7.11.39 · p160 ROCK-1 · p160ROCK · Renal carcinoma antigen NY-REN-35 · Rho-associated, coiled-coil-containing protein kinase 1

Resolves to

Protein
UniProtQ13464UniProt nameROCK1_HUMAN
Gene
HGNCHGNC:10251NCBI Gene6093GenBank1276901GeneCardsROCK1
Pharmacology
IUPHAR/GtoPdb1503KEGGhsa:6093
Structure
PDB1S1CPDB2ESMPDB2ETK
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Rho-associated protein kinase 1, how selective are they, and which programs against it are still in active trials?

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