Kininogen-1

BE0001017ProteinHumansKNG1

Kininogens are inhibitors of thiol proteases. It is acted on by 9 drugs in DrugBank.

Gene name
KNG1
UniProtKB entry
P01042Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
644 residues · 71,957 Da
Also known as
Alpha-2-thiol proteinase inhibitor · BDK · Fitzgerald factor · High molecular weight kininogen · HMWK

Resolves to

Protein
UniProtP01042UniProt nameKNG1_HUMAN
Gene
HGNCHGNC:6383NCBI Gene3827GenBank177890GeneCardsKNG1
Pharmacology
KEGGhsa:3827
Structure
PDB1NY2PDB2WOKPDB4ASQ
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kininogen-1, how selective are they, and which programs against it are still in active trials?

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