Mucin-2

BE0001034ProteinHumansMUC2

Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:17058067, PubMed:19432394, PubMed:33031746). It is acted on by 3 drugs in DrugBank.

Gene name
MUC2
UniProtKB entry
Q02817Swiss-Prot
Cellular location
Secreted
Residues / weight
5,289 residues · 550,846 Da
Also known as
Intestinal mucin-2 · MUC-2 · SMUC

Resolves to

Protein
UniProtQ02817UniProt nameMUC2_HUMAN
Gene
HGNCHGNC:7512NCBI Gene4583GenBank454154GeneCardsMUC2
Pharmacology
KEGGhsa:4583
Structure
PDB6RBFPDB6TM2PDB6TM6
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mucin-2, how selective are they, and which programs against it are still in active trials?

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