von Willebrand factor

BE0001043ProteinHumansVWF

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. It is acted on by 20 drugs in DrugBank.

Gene name
VWF
UniProtKB entry
P04275Swiss-Prot
Cellular location
Secreted
Residues / weight
2,813 residues · 309,262 Da
Also known as
F8VWF · vWF

Resolves to

Protein
UniProtP04275UniProt nameVWF_HUMAN
Gene
HGNCHGNC:12726NCBI Gene7450GenBank37947GeneCardsVWF
Pharmacology
KEGGhsa:7450
Structure
PDB1AO3PDB1ATZPDB1AUQ
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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24Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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119+ReferencesStructured and connected to the statements they support
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Which approved drugs act on von Willebrand factor, how selective are they, and which programs against it are still in active trials?

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