Vonicog alfa

Von Willebrand factor (vWF) is an endogenous plasma protein essential for primary hemostasis. It acts as an adhesion molecule that binds platelets at the injury site or facilitates platelets to bind themselves to form a platelet plug to stop bleeding. vWF also stabilizes Factor VIII (FVIII) by acting as its carrier protein to attenuate its degradation.

Von Willebrand disease (VWD) is an inherited autosomal bleeding disorder associated with low levels of functional vWF, leading to prolonged bleeding. Vonicog alfa mimics the biological actions of vWF. It promotes platelet adhesion to the vascular sub-endothelium at the site of vascular damage by binding to the vascular sub-endothelium matrix and the platelet membrane. Vonicog alfa also binds to and stabilizes endogenous factor VIII, attenuating its degradation and restoring the FVIII:C level to normal.