Glycogen synthase kinase-3 beta

BE0001065ProteinHumansGSK3B

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2),... It is acted on by 38 drugs in DrugBank.

Gene name
GSK3B
UniProtKB entry
P49841Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
420 residues · 46,744 Da
Also known as
2.7.11.26 · GSK-3 beta · Serine/threonine-protein kinase GSK3B

Resolves to

Protein
UniProtP49841UniProt nameGSK3B_HUMAN
Gene
HGNCHGNC:4617NCBI Gene2932GenBank529237GeneCardsGSK3B
Pharmacology
IUPHAR/GtoPdb2030KEGGhsa:2932
Structure
PDB1GNGPDB1H8FPDB1I09
Drugs

What you can answer from here — as of September 07, 2019

38DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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78GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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144+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycogen synthase kinase-3 beta, how selective are they, and which programs against it are still in active trials?

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