GTPase HRas

BE0001076ProteinHumansHRAS

Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22821884). It is acted on by 9 drugs in DrugBank.

Gene name
HRAS
UniProtKB entry
P01112Swiss-Prot
Cellular location
Cell membrane
Residues / weight
189 residues · 21,298 Da
Also known as
3.6.5.2 · c-H-ras · H-Ras-1 · Ha-Ras · HRAS1

Resolves to

Protein
UniProtP01112UniProt nameRASH_HUMAN
Gene
HGNCHGNC:5173NCBI Gene3265GenBank190891GeneCardsHRAS
Pharmacology
IUPHAR/GtoPdb2822KEGGhsa:3265
Structure
PDB10DCPDB121PPDB1AA9
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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14Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which approved drugs act on GTPase HRas, how selective are they, and which programs against it are still in active trials?

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