This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- AS-101
- DrugBank Accession Number
- DB17740
- Background
AS-101 is an investigational compound with anti-tumour 1 and anti-inflammatory properties.2
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for AS-101 (DB17740)
- Weight
- Average: 312.04
Monoisotopic: 312.8682844 - Chemical Formula
- C2H8Cl3NO2Te
- Synonyms
- Ammonium trichloro(dioxyethylene-o,o')tellurium(iv)
- Ammonium trichlorotellurate
- Ossirene
- External IDs
- AS-101
- AS101
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Adjuvants, Immunologic
- Alkenes
- Anti-Infective Agents
- Antineoplastic Agents
- Antiviral Agents
- Compounds used in a research, industrial, or household setting
- Enzyme Inhibitors
- Hydrocarbons, Acyclic
- Immunologic Factors
- Nucleic Acid Synthesis Inhibitors
- Protective Agents
- Radiation-Protective Agents
- Reverse Transcriptase Inhibitors
- Tellurium
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 708681952A
- CAS number
- 106566-58-9
- InChI Key
- AXWLPMGUUAIGJK-UHFFFAOYSA-O
- InChI
- InChI=1S/C2H4Cl3O2Te.H3N/c3-8(4,5)6-1-2-7-8;/h1-2H2;1H3/q-1;/p+1
- IUPAC Name
- ammonium 2,2,2-trichloro-1,3,2lambda4-dioxatellurolan-2-uide
- SMILES
- [NH4+].Cl[Te-]1(Cl)(Cl)OCCO1
References
- General References
- Sredni B, Weil M, Khomenok G, Lebenthal I, Teitz S, Mardor Y, Ram Z, Orenstein A, Kershenovich A, Michowiz S, Cohen YI, Rappaport ZH, Freidkin I, Albeck M, Longo DL, Kalechman Y: Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res. 2004 Mar 1;64(5):1843-52. doi: 10.1158/0008-5472.can-03-3179. [Article]
- Brodsky M, Yosef S, Galit R, Albeck M, Longo DL, Albeck A, Sredni B: The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme. J Interferon Cytokine Res. 2007 Jun;27(6):453-62. doi: 10.1089/jir.2007.0168. [Article]
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 2.11 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 18.46 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 30.53 m3·mol-1 Chemaxon Polarizability 15.8 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 03, 2023 16:23 / Updated at May 04, 2023 06:06