Endoplasmic reticulum chaperone BiP

BE0001098ProteinHumansHSPA5

Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). It is acted on by 8 drugs in DrugBank.

Gene name
HSPA5
UniProtKB entry
P11021Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
654 residues · 72,332 Da
Also known as
3.6.4.10 · 78 kDa glucose-regulated protein · Binding-immunoglobulin protein · BiP · GRP-78

Resolves to

Protein
UniProtP11021UniProt nameBIP_HUMAN
Gene
HGNCHGNC:5238NCBI Gene3309GenBank386758GeneCardsHSPA5
Pharmacology
KEGGhsa:3309
Structure
PDB3IUCPDB3LDLPDB3LDN
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
21GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
41+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Endoplasmic reticulum chaperone BiP, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In