Butoconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. A medication used to treat yeast infections.
- Mechanism
- Curator reviewed
The exact mechanism of the antifungal action of butoconazole is unknown, however, it is presumed to function as other imidazole derivatives via inhibition of steroid synthesis. Imidazoles generally inhibit the conversion of lanosterol to ergosterol via the inhibition of the enzyme cytochrome P450 14α-demethylase, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.
- Primary indication
- For the local treatment of vulvovaginal candidiasis (infections caused by Candida)Curator reviewed · 1 structured indication
- Formula / weight
- C19H17Cl3N2S · 411.776 g/mol (avg)
- First approval
- Canada, 2003 · United States, 2003
- Code names
- RS 35887 · RS 35887-00-10-3 · RS 35887-10-3
- Brand names
Resolves to
SWLMUYACZKCSHZ-UHFFFAOYSA-NSMILESClC1=CC=C(CCC(CN2C=CN=C2)SC2=C(Cl)C=CC=C2Cl)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Butoconazole, and which of those have an active Phase 3 trial?
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