Hexokinase-1

BE0001108ProteinHumansHK1

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). It is acted on by 10 drugs in DrugBank.

Gene name
HK1
UniProtKB entry
P19367Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
917 residues · 102,485 Da
Also known as
2.7.1.1 · Brain form hexokinase · Hexokinase type I · Hexokinase-A · HK I

Resolves to

Protein
UniProtP19367UniProt nameHXK1_HUMAN
Gene
HGNCHGNC:4922NCBI Gene3098GenBank184021GeneCardsHK1
Pharmacology
KEGGhsa:3098
Structure
PDB1CZAPDB1DGKPDB1HKB
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hexokinase-1, how selective are they, and which programs against it are still in active trials?

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