Methylated-DNA--protein-cysteine methyltransferase

BE0001145ProteinHumansMGMT

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. It is acted on by 12 drugs in DrugBank.

Gene name
MGMT
UniProtKB entry
P16455Swiss-Prot
Cellular location
Nucleus
Residues / weight
207 residues · 21,646 Da
Also known as
2.1.1.63 · 6-O-methylguanine-DNA methyltransferase · MGMT · O-6-methylguanine-DNA-alkyltransferase

Resolves to

Protein
UniProtP16455UniProt nameMGMT_HUMAN
Gene
HGNCHGNC:7059NCBI Gene4255GenBank34559GeneCardsMGMT
Pharmacology
KEGGhsa:4255
Structure
PDB1EH6PDB1EH7PDB1EH8
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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109Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylated-DNA--protein-cysteine methyltransferase, how selective are they, and which programs against it are still in active trials?

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