Dipeptidase 1

BE0001148ProteinHumansDPEP1

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:31442408, PubMed:32325220, PubMed:6334084). It is acted on by 8 drugs in DrugBank.

Gene name
DPEP1
UniProtKB entry
P16444Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
411 residues · 45,673 Da
Also known as
3.4.13.19 · Beta-lactamase · Dehydropeptidase-I · hRDP · MDP

Resolves to

Protein
UniProtP16444UniProt nameDPEP1_HUMAN
Gene
HGNCHGNC:3002NCBI Gene1800GenBank219600GeneCardsDPEP1
Pharmacology
KEGGhsa:1800
Structure
PDB1ITQPDB1ITU
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dipeptidase 1, how selective are they, and which programs against it are still in active trials?

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