Meropenem is a carbapenem antibiotic used to treat a wide variety of infections in the body. It is active against Gram-positive and Gram-negative bacteria.
- Mechanism
- Curator reviewed
The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.
- Primary indication
- For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase...Curator reviewed · 5 structured indications
- Formula / weight
- C17H25N3O5S · 383.463 g/mol (avg)
- First approval
- Canada, 2012 · United States, 1996 · European Union, 2020
- Code names
- Antibiotic SM 7338 · ICI 194660 · SM 7338
- Brand names
Resolves to
DMJNNHOOLUXYBV-PQTSNVLCSA-NSMILES[H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)[C@H](C)[C@]12[H]What you can answer from here — as of September 23, 2026
Which drugs share a target with Meropenem, and which of those have an active Phase 3 trial?
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