Tolinapant

DB16160InvestigationalSmall molecule

ASTX660 is under investigation in clinical trial NCT02503423 (Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas).

Chemical structure of Tolinapant
Formula / weight
C30H42FN5O3 · 539.696 g/mol (avg)
Code names
ASTX-660

Resolves to

Compound
UNII2LHZ9ZC3YOCAS1799328-86-1ChEMBLCHEMBL4173974
Structure
InChIKeyYCXOHEXZVKOGEV-DNRQZRRGSA-NSMILESC[C@@H]1CN(CC(=O)N2CC(C)(C)C3=C2C=C(CC2=CC=C(F)C=C2)C(CO)=N3)[C@@H](CN2CCOC[C@H]2C)CN1
Targets
P98170XIAP

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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10Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Tolinapant, and which of those have an active Phase 3 trial?

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