Caspase-3

BE0001162ProteinHumansCASP3

Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). It is acted on by 22 drugs in DrugBank.

Gene name
CASP3
UniProtKB entry
P42574Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
277 residues · 31,608 Da
Also known as
3.4.22.56 · Apopain · CASP-3 · CPP-32 · CPP32

Resolves to

Protein
UniProtP42574UniProt nameCASP3_HUMAN
Gene
HGNCHGNC:1504NCBI Gene836GenBank561666GeneCardsCASP3
Pharmacology
IUPHAR/GtoPdb1619KEGGhsa:836
Structure
PDB1CP3PDB1GFWPDB1I3O
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
22Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
30GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
49+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Caspase-3, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In