Insulin-degrading enzyme

BE0001183ProteinHumansIDE

Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:10684867, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446,... It is acted on by 11 drugs in DrugBank.

Gene name
IDE
UniProtKB entry
P14735Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,019 residues · 117,967 Da
Also known as
3.4.24.56 · Abeta-degrading protease · Insulin protease · Insulinase · Insulysin

Resolves to

Protein
UniProtP14735UniProt nameIDE_HUMAN
Gene
HGNCHGNC:5381NCBI Gene3416GenBank184556GeneCardsIDE
Pharmacology
IUPHAR/GtoPdb2371KEGGhsa:3416
Structure
PDB2G47PDB2G48PDB2G49
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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25GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Insulin-degrading enzyme, how selective are they, and which programs against it are still in active trials?

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