Rhodopsin

BE0001200ProteinHumansRHO

G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions (PubMed:6140680, PubMed:7846071, PubMed:8107847). It is acted on by 14 drugs in DrugBank.

Gene name
RHO
UniProtKB entry
P08100Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
348 residues · 38,892 Da
Also known as
OPN2 · Opsin-2

Resolves to

Protein
UniProtP08100UniProt nameOPSD_HUMAN
Gene
HGNCHGNC:10012NCBI Gene6010GenBank1236137GeneCardsRHO
Pharmacology
KEGGhsa:6010
Structure
PDB4ZWJPDB5DGYPDB5W0P
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Rhodopsin, how selective are they, and which programs against it are still in active trials?

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