Identification

Summary

N-Acetylmethionine is an amino acid used as a peritoneal dialysis treatment in patients with renal failure and nutritional therapy in patients with nutritional deficiency or post-infection weakness.

Generic Name
N-Acetylmethionine
DrugBank Accession Number
DB01646
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 191.248
Monoisotopic: 191.061613977
Chemical Formula
C7H13NO3S
Synonyms
  • (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid
  • Acetyl-L-methionine
  • Acetylmethionine
  • AcMet
  • L-(N-Acetyl)methionine
  • Methionamine
  • Methionin
  • N-Ac-Met
  • N-acetyl-L-methionine
  • Nα-acetyl-L-methionine
  • Thiomedon

Pharmacology

Indication

Not Available

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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
URhodopsinNot AvailableHumans
UN-acylamino acid racemaseNot AvailableAmycolatopsis sp.
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Follicusan
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2000 ML ÇİFTLİ TORBAN-Acetylmethionine (850 mg/L) + Alanine (951 mg/L) + Arginine (1071 mg/L) + Calcium chloride dihydrate (184 mg/L) + Glycine (510 mg/L) + Histidine (714 mg/L) + Isoleucine (850 mg/L) + Sodium lactate (4480 mg/L) + Leucine (1020 mg/L) + Lysine hydrochloride (955 mg/L) + Magnesium chloride hexahydrate (51 mg/L) + Phenylalanine (570 mg/L) + Proline (595 mg/L) + Serine (510 mg/L) + Sodium chloride (5380 mg/L) + Threonine (646 mg/L) + Tryptophan (270 mg/L) + Tyrosine (300 mg/L) + Valine (1393 mg/L)SolutionIntraperitonealPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2000 ML TEKLİ TORBAN-Acetylmethionine (850 mg/L) + Alanine (951 mg/L) + Arginine (1071 mg/L) + Calcium chloride dihydrate (184 mg/L) + Glycine (510 mg/L) + Histidine (714 mg/L) + Isoleucine (850 mg/L) + Sodium lactate (4480 mg/L) + Leucine (1020 mg/L) + Lysine hydrochloride (955 mg/L) + Magnesium chloride hexahydrate (51 mg/L) + Phenylalanine (570 mg/L) + Proline (595 mg/L) + Serine (510 mg/L) + Sodium chloride (5380 mg/L) + Threonine (646 mg/L) + Tryptophan (270 mg/L) + Tyrosine (300 mg/L) + Valine (1393 mg/L)SolutionIntraperitonealPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2500 ML ÇİFTLİ TORBAN-Acetylmethionine (850 mg/L) + Alanine (951 mg/L) + Arginine (1071 mg/L) + Calcium chloride dihydrate (184 mg/L) + Glycine (510 mg/L) + Histidine (714 mg/L) + Isoleucine (850 mg/L) + Sodium lactate (4480 mg/L) + Leucine (1020 mg/L) + Lysine hydrochloride (955 mg/L) + Magnesium chloride hexahydrate (51 mg/L) + Phenylalanine (570 mg/L) + Proline (595 mg/L) + Serine (510 mg/L) + Sodium chloride (5380 mg/L) + Threonine (646 mg/L) + Tryptophan (270 mg/L) + Tyrosine (300 mg/L) + Valine (1393 mg/L)SolutionIntraperitonealPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2500 ML TEKLİ TORBAN-Acetylmethionine (850 mg/L) + Alanine (951 mg/L) + Arginine (1071 mg/L) + Calcium chloride dihydrate (184 mg/L) + Glycine (510 mg/L) + Histidine (714 mg/L) + Isoleucine (850 mg/L) + Sodium lactate (4480 mg/L) + Leucine (1020 mg/L) + Lysine hydrochloride (955 mg/L) + Magnesium chloride hexahydrate (51 mg/L) + Phenylalanine (570 mg/L) + Proline (595 mg/L) + Serine (510 mg/L) + Sodium chloride (5380 mg/L) + Threonine (646 mg/L) + Tryptophan (270 mg/L) + Tyrosine (300 mg/L) + Valine (1393 mg/L)SolutionIntraperitonealPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as methionine and derivatives. These are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Methionine and derivatives
Alternative Parents
N-acyl-L-alpha-amino acids / Thia fatty acids / Acetamides / Secondary carboxylic acid amides / Sulfenyl compounds / Monocarboxylic acids and derivatives / Dialkylthioethers / Carboxylic acids / Organopnictogen compounds / Organonitrogen compounds
show 3 more
Substituents
Acetamide / Aliphatic acyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid / Dialkylthioether / Fatty acid / Fatty acyl / Hydrocarbon derivative / Methionine or derivatives
show 15 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
monocarboxylic acid, methyl sulfide, N-acetyl-L-amino acid, L-methionine derivative (CHEBI:21557)
Affected organisms
Not Available

Chemical Identifiers

UNII
9J12WX5B6A
CAS number
65-82-7
InChI Key
XUYPXLNMDZIRQH-LURJTMIESA-N
InChI
InChI=1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1
IUPAC Name
(2S)-2-acetamido-4-(methylsulfanyl)butanoic acid
SMILES
CSCC[C@H](NC(C)=O)C(O)=O

References

Synthesis Reference

Hans Wagner, Alfred Maierhofer, "Process for the production of N-acetyl-L-methionine." U.S. Patent US4011263, issued 1968.

US4011263
General References
Not Available
KEGG Compound
C02712
PubChem Compound
448580
PubChem Substance
46506781
ChemSpider
395338
RxNav
1426463
ChEBI
21557
ZINC
ZINC000001529501
PDBe Ligand
AME
PDB Entries
1sja / 3q6u / 3tgu / 4a6g / 4gao / 4gba / 4iwd / 4p5o / 4ycm / 4ycn
show 20 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntraperitoneal
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)105.5 °CPhysProp
water solubility3.07E+005 mg/L (at 25 °C)BEILSTEIN
Predicted Properties
PropertyValueSource
Water Solubility6.84 mg/mLALOGPS
logP-0.15ALOGPS
logP-0.11ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)4.02ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.4 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity47.03 m3·mol-1ChemAxon
Polarizability19.59 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9079
Blood Brain Barrier+0.962
Caco-2 permeable-0.6724
P-glycoprotein substrateNon-substrate0.5397
P-glycoprotein inhibitor INon-inhibitor0.93
P-glycoprotein inhibitor IINon-inhibitor0.963
Renal organic cation transporterNon-inhibitor0.9411
CYP450 2C9 substrateNon-substrate0.7849
CYP450 2D6 substrateNon-substrate0.7976
CYP450 3A4 substrateNon-substrate0.5608
CYP450 1A2 substrateNon-inhibitor0.8618
CYP450 2C9 inhibitorNon-inhibitor0.8988
CYP450 2D6 inhibitorNon-inhibitor0.9613
CYP450 2C19 inhibitorNon-inhibitor0.9375
CYP450 3A4 inhibitorNon-inhibitor0.9837
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.992
Ames testNon AMES toxic0.7591
CarcinogenicityNon-carcinogens0.9472
BiodegradationReady biodegradable0.6811
Rat acute toxicity1.5530 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9928
hERG inhibition (predictor II)Non-inhibitor0.9625
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (2 TMS)GC-MSsplash10-0v4j-2920000000-21fd3a4d7b12ac2aca3c
GC-MS Spectrum - GC-MS (1 TMS)GC-MSsplash10-0002-6900000000-3e9fc6c1775a4e3d390a
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-1900000000-15861132c8b2269198ae
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udj-2900000000-dfeda97a2049e74815ce
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0w2m-9400000000-6da930234f6033225c78
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0005-4900000000-fd1e8a8512a5adc4f78b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9500000000-ba3c2cf457f39b90d9b0
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-63ccb712a985eedfd16a
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0006-0900000000-08cead5b5b6a03d6ba5a
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0005-1900000000-d059fe0be6d1a5b4b084
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-9100000000-43df5a1503ce3f2cf758
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-9000000000-b757a5078c71037ef5b6
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-9000000000-275fc8f00e0ba4f1dbea
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0006-0900000000-4826c0abe069970d9768
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0udj-3900000000-947d106e4353bbea5449
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0k92-9500000000-5171045a6fc50c4963f9
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-08fr-9100000000-2e49b493225ec50c951f
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-9000000000-df7f02d0426ee253bc2b

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Photoreceptor activity
Specific Function
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a ...
Gene Name
RHO
Uniprot ID
P08100
Uniprot Name
Rhodopsin
Molecular Weight
38892.335 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Amycolatopsis sp.
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
Aaar
Uniprot ID
Q44244
Uniprot Name
o-succinylbenzoate synthase
Molecular Weight
39406.005 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]

Drug created at June 13, 2005 13:24 / Updated at May 05, 2021 20:30