Streptogramin A acetyltransferase

BE0001238ProteinEnterococcus faeciumvatD

Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics. It is acted on by 3 drugs in DrugBank.

Gene name
vatD
UniProtKB entry
P50870Swiss-Prot
Residues / weight
209 residues · 23,649 Da
Also known as
2.3.1.- · satA · Vat(D) · Virginiamycin acetyltransferase D

Resolves to

Protein
UniProtP50870UniProt nameVATD_ENTFC
Gene
GenBank433715
Pharmacology
KEGGag:AAA24783
Structure
PDB1KHRPDB1KK4PDB1KK5
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Streptogramin A acetyltransferase, how selective are they, and which programs against it are still in active trials?

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