Isocitrate dehydrogenase [NADP] cytoplasmic

BE0001251ProteinHumansIDH1

Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). It is acted on by 10 drugs in DrugBank.

Gene name
IDH1
UniProtKB entry
O75874Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
414 residues · 46,659 Da
Also known as
1.1.1.42 · Cytosolic NADP-isocitrate dehydrogenase · IDH · IDH1 · IDPc

Resolves to

Protein
UniProtO75874UniProt nameIDHC_HUMAN
Gene
HGNCHGNC:5382NCBI Gene3417GenBank3641398GeneCardsIDH1
Pharmacology
IUPHAR/GtoPdb2884KEGGhsa:3417
Structure
PDB1T09PDB1T0LPDB3INM
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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39Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isocitrate dehydrogenase [NADP] cytoplasmic, how selective are they, and which programs against it are still in active trials?

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