Indocyanine green is a diagnostic agent used for the determination of cardiac output, hepatic function and liver blood flow, and for ophthalmic angiography. Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm.
- Mechanism
- Curator reviewed
Indocyanine Green for Injection USP undergoes no significant extrahepatic or enterohepatic circulation; simultaneous arterial and venous blood estimations have shown negligible renal, peripheral, lung or cerebro-spinal uptake of the dye. Indocyanine Green for Injection USP is taken up from the plasma almost exclusively by the hepatic parenchymal cells and is secreted entirely into the bile. After biliary obstruction, the dye appears in the hepatic lymph, independently of the bile, suggesting that the biliary mucosa is sufficiently intact to prevent diffusion of the dye, though allowing diffusion of bilirubin. These characteristics make Indocyanine Green for Injection USP a helpful index of hepatic function.
- Primary indication
- For Determining Cardiac Output, Hepatic Function and Liver Blood Flow For ophthalmic angiographyCurator reviewed · 12 structured indications
- Formula / weight
- C43H48N2O6S2 · 752.99 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1981
- Code names
- Crysta-lyn 551522 · NK-5078
- Brand names
Resolves to
BDBMLMBYCXNVMC-UHFFFAOYSA-NSMILESCC1(C)C(=CC=CC=CC=CC2=[N+](CCCCS([O-])(=O)=O)C3=CC=C4C=CC=CC4=C3C2(C)C)N(CCCCS(O)(=O)=O)C2=CC=C3C=CC=CC3=C12What you can answer from here — as of September 13, 2026
Which other approved drugs treat the same conditions as Indocyanine green, and which companies have late-stage candidates in those indications?
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