Adenylate kinase isoenzyme 1

BE0001262ProteinHumansAK1

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It is acted on by 5 drugs in DrugBank.

Gene name
AK1
UniProtKB entry
P00568Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
194 residues · 21,635 Da
Also known as
2.7.4.3 · 2.7.4.4 · 2.7.4.6 · Adenylate monophosphate kinase · AK 1

Resolves to

Protein
UniProtP00568UniProt nameKAD1_HUMAN
Gene
HGNCHGNC:361NCBI Gene203GenBank178322GeneCardsAK1
Pharmacology
KEGGhsa:203
Structure
PDB1Z83PDB2C95PDB7DE3
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenylate kinase isoenzyme 1, how selective are they, and which programs against it are still in active trials?

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