Thiamine-phosphate synthase

BE0001327ProteinBacillus subtilis (strain 168)thiE

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). It is acted on by 6 drugs in DrugBank.

Gene name
thiE
UniProtKB entry
P39594Swiss-Prot
Residues / weight
222 residues · 23,681 Da
Also known as
2.5.1.3 · Thiamine-phosphate pyrophosphorylase · thiC · TMP pyrophosphorylase · TMP-PPase

Resolves to

Protein
UniProtP39594UniProt nameTHIE_BACSU
Gene
NCBI Gene937316
Pharmacology
KEGGbsu:BSU38290
Structure
PDB1G4EPDB1G4PPDB1G4S
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thiamine-phosphate synthase, and which indications are they being tested in?

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