Protein kinase C theta type

BE0001385ProteinHumansPRKCQ

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1... It is acted on by 5 drugs in DrugBank.

Gene name
PRKCQ
UniProtKB entry
Q04759Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
706 residues · 81,864 Da
Also known as
2.7.11.13 · nPKC-theta · PRKCT

Resolves to

Protein
UniProtQ04759UniProt nameKPCT_HUMAN
Gene
HGNCHGNC:9410NCBI Gene5588GenBank558099GeneCardsPRKCQ
Pharmacology
IUPHAR/GtoPdb1488KEGGhsa:5588
Structure
PDB1XJDPDB2ENJPDB2ENN
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein kinase C theta type, how selective are they, and which programs against it are still in active trials?

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