Tubulin alpha-4A chain

BE0001391ProteinHumansTUBA4A

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. It is acted on by 6 drugs in DrugBank.

Gene name
TUBA4A
UniProtKB entry
P68366Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
448 residues · 49,924 Da
Also known as
3.6.5.- · Alpha-tubulin 1 · Testis-specific alpha-tubulin · TUBA1 · Tubulin alpha-1 chain

Resolves to

Protein
UniProtP68366UniProt nameTBA4A_HUMAN
Gene
HGNCHGNC:12407NCBI Gene7277GenBank32015GeneCardsTUBA4A
Pharmacology
KEGGhsa:7277
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tubulin alpha-4A chain, how selective are they, and which programs against it are still in active trials?

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