Epothilone D

DB01873InvestigationalSmall molecule

Investigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.

Mechanism: The principal mechanism of the epothilone class is inhibition of microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing.
Curator reviewed
Primary indication: Investigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.Curator reviewed
Formula / weight: C₂₇H₄₁NO₅S · 491.683 g/mol (avg)
Also known as: 12,13-desoxyepothilone B · Desoxyepothilone B
Code names: KOS-862 · NSC-703147 · R-1492

Resolves to

Compound

Structure

InChIKeyXOZIUKBZLSUILX-GIQCAXHBSA-NSMILES[H][C@]1(C\C=C(C)/CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)C(\C)=C\C1=CSC(C)=N1

Targets

What you can answer from here — as of September 12, 2026

11Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

323Drug interactionsStructured to mechanism, not free text

6Clinical trialsPhase, status and sponsor resolved per trial

23+ReferencesStructured and connected to the statements they support

Which drugs share a target with Epothilone D, and which of those have an active Phase 3 trial?

Create a free account or log in to explore the full data card.