Tubulin beta-3 chain

BE0001415ProteinHumansTUBB3

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). It is acted on by 6 drugs in DrugBank.

Gene name
TUBB3
UniProtKB entry
Q13509Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
450 residues · 50,432 Da
Also known as
TUBB4 · Tubulin beta-4 chain · Tubulin beta-III

Resolves to

Protein
UniProtQ13509UniProt nameTBB3_HUMAN
Gene
HGNCHGNC:20772NCBI Gene10381GenBank1297274GeneCardsTUBB3
Pharmacology
IUPHAR/GtoPdb2752KEGGhsa:10381
Structure
PDB22AJPDB22AKPDB5IJ0
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tubulin beta-3 chain, how selective are they, and which programs against it are still in active trials?

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