Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

BE0001423ProteinEscherichia coli (strain K12)glmS

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. It is acted on by 7 drugs in DrugBank.

Gene name
glmS
UniProtKB entry
P17169Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
609 residues · 66,894 Da
Also known as
2.6.1.16 · D-fructose-6-phosphate amidotransferase · GFAT · Glucosamine-6-phosphate synthase · Hexosephosphate aminotransferase

Resolves to

Protein
UniProtP17169UniProt nameGLMS_ECOLI
Gene
NCBI Gene948241GenBank43268
Pharmacology
KEGGecj:JW3707
Structure
PDB1JXAPDB1MOQPDB1MOR
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Glutamine--fructose-6-phosphate aminotransferase [isomerizing], and which indications are they being tested in?

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