6,7-dimethyl-8-ribityllumazine synthase

BE0001449ProteinAquifex aeolicus (strain VF5)ribH

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. It is acted on by 3 drugs in DrugBank.

Gene name
ribH
UniProtKB entry
O66529Swiss-Prot
Residues / weight
154 residues · 16,705 Da
Also known as
2.5.1.78 · DMRL synthase

Resolves to

Protein
UniProtO66529UniProt nameRISB_AQUAE
Gene
NCBI Gene1192672GenBank2982869
Pharmacology
KEGGaae:aq_132
Structure
PDB1HQKPDB1NQUPDB1NQV
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 6,7-dimethyl-8-ribityllumazine synthase, and which indications are they being tested in?

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