Tryptase beta-2

BE0001474ProteinHumansTPSB2

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It is acted on by 5 drugs in DrugBank.

Gene name
TPSB2
UniProtKB entry
P20231Swiss-Prot
Cellular location
Secreted
Residues / weight
275 residues · 30,651 Da
Also known as
3.4.21.59 · TPS2 · Tryptase II · Tryptase-2

Resolves to

Protein
UniProtP20231UniProt nameTRYB2_HUMAN
Gene
HGNCHGNC:14120NCBI Gene64499GenBank179584GeneCardsTPSB2
Pharmacology
KEGGhsa:64499
Structure
PDB1A0LPDB2BM2PDB2FPZ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptase beta-2, how selective are they, and which programs against it are still in active trials?

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