Tryptase beta-2
Details
- Name
- Tryptase beta-2
- Kind
- protein
- Synonyms
- 3.4.21.59
- TPS2
- Tryptase II
- Tryptase-2
- Gene Name
- TPSB2
- UniProtKB Entry
- P20231Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0056075|Tryptase beta-2 MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCG GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
- Number of residues
- 275
- Molecular Weight
- 30651.07
- Theoretical pI
- 7.12
- GO Classification
- Functionsserine-type endopeptidase activity / serine-type peptidase activityProcessesproteolysisComponentsextracellular space
- General Function
- Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity
- Specific Function
- serine-type endopeptidase activity
- Pfam Domain Function
- Trypsin (PF00089)
- Signal Regions
- 1-18
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0011039|Tryptase beta-2 (TPSB2) ATGCTGAATCTGCTGCTGCTGGCGCTGCCCGTCCTGGCGAGCCGCGCCTACGCGGCCCCT GCCCCAGGCCAGGCCCTGCAGCGAGTGGGCATCGTTGGGGGTCAGGAGGCCCCCAGGAGC AAGTGGCCCTGGCAGGTGAGCCTGAGAGTCCGCGACCGATACTGGATGCACTTCTGCGGG GGCTCCCTCATCCACCCCCAGTGGGTGCTGACCGCAGCGCACTGCGTGGGACCGGACGTC AAGGATCTGGCCGCCCTCAGGGTGCAACTGCGGGAGCAGCACCTCTACTACCAGGACCAG CTGCTGCCGGTCAGCAGGATCATCGTGCACCCACAGTTCTACACCGCCCAGATCGGAGCG GACATCGCCCTGCTGGAGCTGGAGGAGCCGGTGAACGTCTCCAGCCACGTCCACACGGTC ACCCTGCCCCCTGCCTCAGAGACCTTCCCCCCGGGGATGCCGTGCTGGGTCACTGGCTGG GGCGATGTGGACAATGATGAGCGCCTCCCACCGCCATTTCCTCTGAAGCAGGTGAAGGTC CCCATAATGGAAAACCACATTTGTGACGCAAAATACCACCTTGGCGCCTACACGGGAGAC GACGTCCGCATCGTCCGTGACGACATGCTGTGTGCCGGGAACACCCGGAGGGACTCATGC CAGGGCGACTCCGGAGGGCCCCTGGTGTGCAAGGTGAATGGCACCTGGCTGCAGGCGGGC GTGGTCAGCTGGGGCGAGGGCTGTGCCCAGCCCAACCGGCCTGGCATCTACACCCGTGTC ACCTACTACTTGGACTGGATCCACCACTATGTCCCCAAAAAGCCGTGA
- Chromosome Location
- 16
- Locus
- 16p13.3
- External Identifiers
Resource Link UniProtKB ID P20231 UniProtKB Entry Name TRYB2_HUMAN GenBank Protein ID 179584 GenBank Gene ID M37488 GeneCard ID TPSB2 GenAtlas ID TPSB2 HGNC ID HGNC:14120 PDB ID(s) 1A0L, 2BM2, 2FPZ, 2FS8, 2FS9, 2FWW, 2FXR, 2GDD, 2ZA5, 3V7T KEGG ID hsa:64499 NCBI Gene ID 64499 - General References
- Miller JS, Moxley G, Schwartz LB: Cloning and characterization of a second complementary DNA for human tryptase. J Clin Invest. 1990 Sep;86(3):864-70. [Article]
- Blom T, Hellman L: Characterization of a tryptase mRNA expressed in the human basophil cell line KU812. Scand J Immunol. 1993 Feb;37(2):203-8. [Article]
- Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH: Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. J Biol Chem. 1999 Feb 5;274(6):3355-62. [Article]
- Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH: Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J Allergy Clin Immunol. 2009 Nov;124(5):1099-105.e1-4. doi: 10.1016/j.jaci.2009.07.026. Epub 2009 Sep 12. [Article]
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- Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH: Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc Natl Acad Sci U S A. 1990 May;87(10):3811-5. [Article]
- Strik MC, Wolbink A, Wouters D, Bladergroen BA, Verlaan AR, van Houdt IS, Hijlkema S, Hack CE, Kummer JA: Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood. 2004 Apr 1;103(7):2710-7. Epub 2003 Dec 11. [Article]
- Fukuoka Y, Schwartz LB: Active monomers of human beta-tryptase have expanded substrate specificities. Int Immunopharmacol. 2007 Dec 20;7(14):1900-8. Epub 2007 Jul 27. [Article]
- Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
- Pereira PJ, Bergner A, Macedo-Ribeiro S, Huber R, Matschiner G, Fritz H, Sommerhoff CP, Bode W: Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Nature. 1998 Mar 19;392(6673):306-11. [Article]
- Sommerhoff CP, Bode W, Pereira PJ, Stubbs MT, Sturzebecher J, Piechottka GP, Matschiner G, Bergner A: The structure of the human betaII-tryptase tetramer: fo(u)r better or worse. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10984-91. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Amido Phenyl Pyruvic Acid experimental unknown target Details 4-PIPERIDIN-4-YLBUTANAL experimental unknown target Details [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE experimental unknown target Details JNJ-27390467 experimental unknown target Details