N-terminome analysis of the human mitochondrial proteome.
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Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C
N-terminome analysis of the human mitochondrial proteome.
Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8.
- PubMed ID
- 25944712 [ View in PubMed]
- Abstract
The high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the free N-terminome analysis of human mitochondria-enriched samples using trimethoxyphenyl phosphonium (TMPP) labelling approaches. Owing to the extent of protein import and cleavage for mitochondrial proteins, determining the new N-termini generated after translocation/processing events for mitochondrial proteins is crucial to understand the transformation of precursors to mature proteins. The doublet N-terminal oriented proteomics (dN-TOP) strategy based on a double light/heavy TMPP labelling has been optimized in order to improve and automate the workflow for efficient, fast and reliable high throughput N-terminome analysis. A total of 2714 proteins were identified and 897 N-terminal peptides were characterized (424 N-alpha-acetylated and 473 TMPP-labelled peptides). These results allowed the precise identification of the N-terminus of 693 unique proteins corresponding to 26% of all identified proteins. Overall, 120 already annotated processing cleavage sites were confirmed while 302 new cleavage sites were characterized. The accumulation of experimental evidence of mature N-termini should allow increasing the knowledge of processing mechanisms and consequently also enhance cleavage sites prediction algorithms. Complete datasets have been deposited to the ProteomeXchange Consortium with identifiers PXD001521, PXD001522 and PXD001523 (http://proteomecentral.proteomexchange.org/dataset/PXD001521, http://proteomecentral.proteomexchange.org/dataset/PXD0001522 and http://proteomecentral.proteomexchange.org/dataset/PXD001523, respectively).
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID NAD(P) transhydrogenase, mitochondrial Q13423 Details Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial P50213 Details Prostaglandin G/H synthase 1 P23219 Details Phenylalanine--tRNA ligase, mitochondrial O95363 Details 7-dehydrocholesterol reductase Q9UBM7 Details Dehydrogenase/reductase SDR family member 4 Q9BTZ2 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial O00217 Details Phenylalanine--tRNA ligase alpha subunit Q9Y285 Details Transketolase P29401 Details Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating Q15738 Details High affinity immunoglobulin epsilon receptor subunit gamma P30273 Details Prolyl 4-hydroxylase subunit alpha-1 P13674 Details Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial P10515 Details L-lactate dehydrogenase B chain P07195 Details Acetyl-CoA acetyltransferase, mitochondrial P24752 Details Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Q9HCC0 Details Hypoxanthine-guanine phosphoribosyltransferase P00492 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial O95299 Details Ferritin light chain P02792 Details Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Q02809 Details Pyruvate kinase PKM P14618 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 O43920 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial O75380 Details Mitochondrial basic amino acids transporter Q8N8R3 Details Pyruvate dehydrogenase E1 component subunit beta, mitochondrial P11177 Details Adenine phosphoribosyltransferase P07741 Details 3-hydroxyisobutyrate dehydrogenase, mitochondrial P31937 Details Hemoglobin subunit alpha P69905 Details NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial P19404 Details AFG3-like protein 2 Q9Y4W6 Details Tubulin beta chain P07437 Details NAD-dependent malic enzyme, mitochondrial P23368 Details Cysteine desulfurase, mitochondrial Q9Y697 Details Sigma non-opioid intracellular receptor 1 Q99720 Details NADH-cytochrome b5 reductase 3 P00387 Details D-3-phosphoglycerate dehydrogenase O43175 Details 2-oxoglutarate dehydrogenase, mitochondrial Q02218 Details Cytochrome c oxidase subunit NDUFA4 O00483 Details NADH dehydrogenase [ubiquinone] 1 subunit C2 O95298 Details D-beta-hydroxybutyrate dehydrogenase, mitochondrial Q02338 Details Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial P31040 Details Carnitine O-palmitoyltransferase 2, mitochondrial P23786 Details Glutamate dehydrogenase 1, mitochondrial P00367 Details Bifunctional glutamate/proline--tRNA ligase P07814 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial O75489 Details Lysine--tRNA ligase Q15046 Details Mitochondrial ornithine transporter 1 Q9Y619 Details Probable leucine--tRNA ligase, mitochondrial Q15031 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 P56556 Details Large neutral amino acids transporter small subunit 1 Q01650 Details Valine--tRNA ligase P26640 Details Pyrroline-5-carboxylate reductase 1, mitochondrial P32322 Details Tyrosine--tRNA ligase, cytoplasmic P54577 Details Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial Q02252 Details Calcium-binding mitochondrial carrier protein Aralar1 O75746 Details Neutral amino acid transporter B(0) Q15758 Details Adrenodoxin, mitochondrial P10109 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial O43674 Details Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial P30038 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 O96000 Details Apoptosis regulator Bcl-2 P10415 Details Purine nucleoside phosphorylase P00491 Details Trifunctional enzyme subunit alpha, mitochondrial P40939 Details Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial P13995 Details Calcium-binding mitochondrial carrier protein Aralar2 Q9UJS0 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 O43676 Details 4-trimethylaminobutyraldehyde dehydrogenase P49189 Details HCG20471, isoform CRA_c Q5T1J1 Details Serine hydroxymethyltransferase, mitochondrial P34897 Details Alanine--tRNA ligase, cytoplasmic P49588 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 O95168 Details Sorbitol dehydrogenase Q00796 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Q16795 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial O75251 Details 3-hydroxyacyl-CoA dehydrogenase type-2 Q99714 Details Methylmalonic aciduria type A protein, mitochondrial Q8IVH4 Details Cytochrome c oxidase subunit 1 P00395 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 O75438 Details Glycine amidinotransferase, mitochondrial P50440 Details Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Q96I99 Details GDH/6PGL endoplasmic bifunctional protein O95479 Details Tyrosine--tRNA ligase, mitochondrial Q9Y2Z4 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 P51970 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 O95139 Details Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Q16836 Details Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 Details Aspartate aminotransferase, mitochondrial P00505 Details Neutrophil elastase P08246 Details Isovaleryl-CoA dehydrogenase, mitochondrial P26440 Details Ferritin heavy chain P02794 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 O95182 Details Carnitine O-palmitoyltransferase 1, liver isoform P50416 Details Peroxisomal multifunctional enzyme type 2 P51659 Details Calmodulin P0DP23 Details Ornithine aminotransferase, mitochondrial P04181 Details L-lactate dehydrogenase A chain P00338 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial O95178 Details Serine palmitoyltransferase 1 O15269 Details Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Q96RQ3 Details Monocarboxylate transporter 4 O15427 Details Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Q96EY8 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Q16718 Details Aldehyde dehydrogenase X, mitochondrial P30837 Details Neutral amino acid transporter A P43007 Details ATP synthase subunit delta, mitochondrial P30049 Details NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial P49821 Details Isoleucine--tRNA ligase, cytoplasmic P41252 Details NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial P28331 Details Carnitine O-acetyltransferase P43155 Details Low-density lipoprotein receptor P01130 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial O43181 Details NADH-ubiquinone oxidoreductase chain 1 P03886 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 P17568 Details 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial O75600 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Q9P0J0 Details Serum albumin P02768 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Q86Y39 Details Glyceraldehyde-3-phosphate dehydrogenase P04406 Details Acyl carrier protein, mitochondrial O14561 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 O43678 Details NADH-ubiquinone oxidoreductase chain 4 P03905 Details Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial O43837 Details Phenylalanine--tRNA ligase beta subunit Q9NSD9 Details Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 Details Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial P45954 Details Squalene monooxygenase Q14534 Details Mitochondrial carnitine/acylcarnitine carrier protein O43772 Details NADH-ubiquinone oxidoreductase chain 5 P03915 Details Heme oxygenase 2 P30519 Details Malate dehydrogenase, cytoplasmic P40925 Details Integrin alpha-4 P13612 Details Retinol dehydrogenase 13 Q8NBN7 Details Flavin reductase (NADPH) P30043 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Q9Y6M9 Details ADP/ATP translocase 1 P12235 Details Asparagine--tRNA ligase, cytoplasmic O43776 Details C-1-tetrahydrofolate synthase, cytoplasmic P11586 Details ADP/ATP translocase 3 P12236 Details Long-chain-fatty-acid--CoA ligase 1 P33121 Details Glutathione reductase, mitochondrial P00390 Details NADH-ubiquinone oxidoreductase chain 2 P03891 Details Monocarboxylate transporter 1 P53985 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 O95167 Details Pyruvate carboxylase, mitochondrial P11498 Details ADP/ATP translocase 2 P05141 Details Branched-chain-amino-acid aminotransferase, mitochondrial O15382 Details Inosine-5'-monophosphate dehydrogenase 2 P12268 Details Aspartate--tRNA ligase, cytoplasmic P14868 Details Pyrroline-5-carboxylate reductase 2 Q96C36 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial O75306 Details Mitochondrial folate transporter/carrier Q9H2D1 Details Sodium/potassium-transporting ATPase subunit alpha-1 P05023 Details Translocator protein P30536 Details Dihydrolipoyl dehydrogenase, mitochondrial P09622 Details Biliverdin reductase A P53004 Details Acetyl-coenzyme A synthetase 2-like, mitochondrial Q9NUB1 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Q9UI09 Details Short-chain specific acyl-CoA dehydrogenase, mitochondrial P16219 Details Leucine--tRNA ligase, cytoplasmic Q9P2J5 Details Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial P51553 Details Farnesyl pyrophosphate synthase P14324 Details Methylmalonyl-CoA mutase, mitochondrial P22033 Details Malate dehydrogenase, mitochondrial P40926 Details Glutathione S-transferase kappa 1 Q9Y2Q3 Details Glutathione S-transferase P P09211 Details Glutathione S-transferase omega-1 P78417 Details Glutathione peroxidase 1 P07203 Details Delta-1-pyrroline-5-carboxylate synthase P54886 Details Glutaminase kidney isoform, mitochondrial O94925 Details Perilipin-3 O60664 Details L-xylulose reductase Q7Z4W1 Details Lanosterol 14-alpha demethylase Q16850 Details Lysosomal alpha-glucosidase P10253 Details N-acetylgalactosamine-6-sulfatase P34059 Details Peroxiredoxin-5, mitochondrial P30044 Details Eosinophil cationic protein P12724 Details Growth factor receptor-bound protein 2 P62993 Details Sulfotransferase 1A1 P50225 Details Cytochrome b P00156 Details Cathepsin B P07858 Details Cathepsin D P07339 Details Alpha-1-antitrypsin P01009 Details Myeloblastin P24158 Details Phosphatidylinositol 3-kinase regulatory subunit alpha P27986 Details Fatty acid synthase P49327 Details Lactoylglutathione lyase Q04760 Details Apoptosis-inducing factor 1, mitochondrial O95831 Details Beta-glucuronidase P08236 Details Transforming growth factor beta-1 P01137 Details Protein deglycase DJ-1 Q99497 Details Long-chain-fatty-acid--CoA ligase 4 O60488 Details Glycine--tRNA ligase P41250 Details Cytochrome b-c1 complex subunit 1, mitochondrial P31930 Details Cytochrome c P99999 Details Cathepsin G P08311 Details Calnexin P27824 Details Peptidyl-prolyl cis-trans isomerase A P62937 Details Mitogen-activated protein kinase 14 Q16539 Details Ferrochelatase, mitochondrial P22830 Details Integrin beta-2 P05107 Details Choline transporter-like protein 1 Q8WWI5 Details Vitronectin P04004 Details Aminopeptidase N P15144 Details Cyclin-dependent kinase 1 P06493 Details Intercellular adhesion molecule 1 P05362 Details Long-chain-fatty-acid--CoA ligase 3 O95573 Details 78 kDa glucose-regulated protein P11021 Details Phosphatidylserine synthase 1 P48651 Details Hexokinase-1 P19367 Details Ras-related C3 botulinum toxin substrate 1 P63000 Details CD44 antigen P16070 Details Heat shock protein HSP 90-alpha P07900 Details Phospholipid hydroperoxide glutathione peroxidase, mitochondrial P36969 Details Protein-L-isoaspartate(D-aspartate) O-methyltransferase P22061 Details Beta-hexosaminidase subunit beta P07686 Details Inhibitor of nuclear factor kappa-B kinase subunit beta O14920 Details Endothelial protein C receptor Q9UNN8 Details Endoplasmin P14625 Details Annexin A2 P07355 Details Cytochrome b5 P00167 Details 14-3-3 protein zeta/delta P63104 Details Prosaposin P07602 Details Phosphatidylethanolamine-binding protein 1 P30086 Details Quinone oxidoreductase Q08257 Details Transforming protein RhoA P61586 Details Glucose-6-phosphate isomerase P06744 Details Equilibrative nucleoside transporter 1 Q99808 Details Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial P33316 Details Catalase P04040 Details Thymidylate kinase P23919 Details ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Q10588 Details Isocitrate dehydrogenase [NADP] cytoplasmic O75874 Details Tubulin alpha-1B chain P68363 Details Tyrosine-protein kinase BTK Q06187 Details Non-secretory ribonuclease P10153 Details Acetyl-CoA acetyltransferase, cytosolic Q9BWD1 Details Galectin-3 P17931 Details Tubulin beta-4B chain P68371 Details Tubulin alpha-4A chain P68366 Details Peptidyl-prolyl cis-trans isomerase F, mitochondrial P30405 Details Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Q9UKM7 Details Tyrosine-protein kinase HCK P08631 Details Ganglioside GM2 activator P17900 Details Serine/threonine-protein phosphatase PP1-gamma catalytic subunit P36873 Details Lanosterol synthase P48449 Details Tryptase beta-2 P20231 Details Coatomer subunit gamma-1 Q9Y678 Details Cathepsin S P25774 Details Ribonuclease UK114 P52758 Details Fructose-bisphosphate aldolase A P04075 Details Ras-related protein Rab-9A P51151 Details Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 Details Enoyl-CoA delta isomerase 1, mitochondrial P42126 Details Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 Q96T66 Details Macrophage migration inhibitory factor P14174 Details Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 O94766 Details Thromboxane-A synthase P24557 Details Heat shock protein HSP 90-beta P08238 Details Cathepsin L2 O60911 Details Glutaryl-CoA dehydrogenase, mitochondrial Q92947 Details Peroxiredoxin-2 P32119 Details Fatty acid-binding protein, epidermal Q01469 Details Catechol O-methyltransferase P21964 Details Calreticulin P27797 Details Phytanoyl-CoA dioxygenase, peroxisomal O14832 Details Protein ERGIC-53 P49257 Details Multiple coagulation factor deficiency protein 2 Q8NI22 Details Proline synthase co-transcribed bacterial homolog protein O94903 Details Phospholipase D1 Q13393 Details Choline transporter-like protein 2 Q8IWA5 Details Choline/ethanolaminephosphotransferase 1 Q9Y6K0 Details Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 O60568 Details Peptide deformylase, mitochondrial Q9HBH1 Details Prolyl 3-hydroxylase 1 Q32P28 Details Aspartate--tRNA ligase, mitochondrial Q6PI48 Details Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial O75879 Details Fatty acid desaturase 2 O95864 Details Methionine--tRNA ligase, mitochondrial Q96GW9 Details Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial O14521 Details Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial P21912 Details Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial P53597 Details Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial P55809 Details Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Q99643 Details Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial Q9P2R7 Details N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Q9UK23 Details Probable glutamate--tRNA ligase, mitochondrial Q5JPH6 Details Mitochondrial glutamate carrier 1 Q9H936 Details Microsomal glutathione S-transferase 3 O14880 Details Thioredoxin domain-containing protein 12 O95881 Details Microsomal glutathione S-transferase 1 P10620 Details S-formylglutathione hydrolase P10768 Details Glutaredoxin-1 P35754 Details Microsomal glutathione S-transferase 2 Q99735 Details Glycine cleavage system H protein, mitochondrial P23434 Details Tryptophan--tRNA ligase, mitochondrial Q9UGM6 Details Probable cysteine--tRNA ligase, mitochondrial Q9HA77 Details Threonine--tRNA ligase, mitochondrial Q9BW92 Details Alanine--tRNA ligase, mitochondrial Q5JTZ9 Details Retinol dehydrogenase 11 Q8TC12 Details Retinol dehydrogenase 14 Q9HBH5 Details Isoleucine--tRNA ligase, mitochondrial Q9NSE4 Details Vitamin K epoxide reductase complex subunit 1-like protein 1 Q8N0U8 Details Peptidyl-prolyl cis-trans isomerase H O43447 Details Peptidyl-prolyl cis-trans isomerase B P23284 Details Probable asparagine--tRNA ligase, mitochondrial Q96I59 Details Proteasome subunit beta type-1 P20618 Details Proteasome subunit beta type-2 P49721 Details Guanylate kinase Q16774 Details NADPH--cytochrome P450 reductase P16435 Details Arachidonate 5-lipoxygenase-activating protein P20292 Details Phosphatidylinositol 3-kinase regulatory subunit beta O00459 Details DNA-dependent protein kinase catalytic subunit P78527 Details Serine/threonine-protein kinase mTOR P42345 Details Superoxide dismutase [Cu-Zn] P00441 Details 40S ribosomal protein SA P08865 Details Disintegrin and metalloproteinase domain-containing protein 10 O14672 Details DNA-(apurinic or apyrimidinic site) lyase P27695 Details Alpha-galactosidase A P06280 Details Squalene synthase P37268 Details Protein disulfide-isomerase P07237 Details Voltage-dependent anion-selective channel protein 1 P21796 Details Voltage-dependent anion-selective channel protein 2 P45880 Details Voltage-dependent anion-selective channel protein 3 Q9Y277 Details Oxidoreductase HTATIP2 Q9BUP3 Details Prostaglandin E synthase 3 Q15185 Details Probable ATP-dependent RNA helicase DDX6 P26196 Details Wiskott-Aldrich syndrome protein P42768 Details Liver carboxylesterase 1 P23141 Details ATP-dependent Clp protease proteolytic subunit, mitochondrial Q16740 Details Protein S100-A11 P31949 Details Ig gamma-1 chain C region P01857 Details Protein S100-A6 P06703 Details Nucleoside diphosphate kinase A P15531 Details Antigen peptide transporter 1 Q03518 Details 2,4-dienoyl-CoA reductase, mitochondrial Q16698 Details Golgi-associated plant pathogenesis-related protein 1 Q9H4G4 Details Trafficking protein particle complex subunit 3 O43617 Details ADP-ribosylation factor 4 P18085 Details Nucleoside diphosphate kinase B P22392 Details Galactokinase P51570 Details Hydroxymethylglutaryl-CoA lyase, mitochondrial P35914 Details Cytochrome c oxidase subunit 2 P00403 Details Thioredoxin reductase 2, mitochondrial Q9NNW7 Details cAMP-dependent protein kinase type II-alpha regulatory subunit P13861 Details High mobility group protein B1 P09429 Details Heat shock protein beta-1 P04792 Details Ribosome-binding protein 1 Q9P2E9 Details Transmembrane glycoprotein NMB Q14956 Details Microtubule-associated protein 4 P27816 Details Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 P16615 Details HLA class I histocompatibility antigen, A-3 alpha chain P04439 Details Alpha-mannosidase 2 Q16706 Details Bcl-2-like protein 1 Q07817 Details V-type proton ATPase catalytic subunit A P38606 Details Integrin beta-1 P05556 Details Cation-independent mannose-6-phosphate receptor P11717 Details ATP-binding cassette sub-family B member 8, mitochondrial Q9NUT2 Details Guanine nucleotide-binding protein G(s) subunit alpha isoforms short P63092 Details Tryptase alpha/beta-1 Q15661 Details Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform P30153 Details Lysozyme C P61626 Details cAMP-dependent protein kinase catalytic subunit alpha P17612 Details S-phase kinase-associated protein 1 P63208 Details Heat shock cognate 71 kDa protein P11142 Details Beta-2-microglobulin P61769 Details Low molecular weight phosphotyrosine protein phosphatase P24666 Details Dual specificity protein phosphatase 23 Q9BVJ7 Details Endothelin-converting enzyme 1 P42892 Details Serine/threonine-protein phosphatase PP1-alpha catalytic subunit P62136 Details Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Q8IVS2 Details V-type proton ATPase subunit B, brain isoform P21281 Details ADP-ribosylation factor 1 P84077 Details 60S ribosomal protein L13a P40429 Details 60S ribosomal protein L23 P62829 Details 60S ribosomal protein L15 P61313 Details 60S ribosomal protein L19 P84098 Details 60S ribosomal protein L23a P62750 Details 60S ribosomal protein L8 P62917 Details 60S ribosomal protein L3 P39023 Details 60S ribosomal protein L11 P62913 Details NHP2-like protein 1 P55769 Details ATP synthase subunit alpha, mitochondrial P25705 Details ATP synthase subunit beta, mitochondrial P06576 Details ATP synthase subunit gamma, mitochondrial P36542 Details Triosephosphate isomerase P60174 Details Cytochrome c1, heme protein, mitochondrial P08574 Details Cytochrome b-c1 complex subunit 2, mitochondrial P22695 Details Cytochrome b-c1 complex subunit 6, mitochondrial P07919 Details Cytochrome b-c1 complex subunit 8 O14949 Details Cytochrome b-c1 complex subunit Rieske, mitochondrial P47985 Details Cytochrome b-c1 complex subunit 7 P14927 Details Cytochrome b-c1 complex subunit 9 Q9UDW1 Details [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Q15118 Details Cytosol aminopeptidase P28838 Details Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial Q16134 Details Proteasome subunit alpha type-1 P25786 Details Proteasome subunit alpha type-2 P25787 Details Proteasome subunit alpha type-7 O14818 Details Proteasome subunit beta type-4 P28070 Details Retinoid-inducible serine carboxypeptidase Q9HB40 Details Pro-cathepsin H P09668 Details Cytochrome c oxidase subunit 4 isoform 1, mitochondrial P13073 Details Cytochrome c oxidase subunit 3 P00414 Details Cytochrome c oxidase subunit 5A, mitochondrial P20674 Details Cytochrome c oxidase subunit 5B, mitochondrial P10606 Details Cytochrome c oxidase subunit 6C P09669 Details Cytochrome c oxidase subunit 7C, mitochondrial P15954 Details Cytochrome c oxidase subunit 6B1 P14854 Details Isopentenyl-diphosphate Delta-isomerase 1 Q13907 Details GTPase KRas P01116 Details HLA class I histocompatibility antigen, B-27 alpha chain P01889 Details Platelet-activating factor acetylhydrolase IB subunit gamma Q15102 Details Serine/threonine-protein kinase 26 Q9P289 Details Methionine aminopeptidase 1 P53582 Details Profilin-1 P07737 Details Peroxisomal acyl-coenzyme A oxidase 1 Q15067 Details Calpain small subunit 1 P04632 Details Annexin A5 P08758 Details Destrin P60981 Details Cofilin-1 P23528 Details Rho-associated protein kinase 2 O75116 Details Enoyl-CoA delta isomerase 2, mitochondrial O75521 Details ADP-ribosylation factor 6 P62330 Details Poliovirus receptor P15151 Details Actin-related protein 2/3 complex subunit 1B O15143 Details Actin-related protein 2 P61160 Details Actin-related protein 3 P61158 Details Actin-related protein 2/3 complex subunit 2 O15144 Details Actin-related protein 2/3 complex subunit 3 O15145 Details Actin-related protein 2/3 complex subunit 5 O15511 Details Elongation factor 2 P13639 Details Tyrosine-protein kinase Lyn P07948 Details 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 Details [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial Q15120 Details Protein S100-A4 P26447 Details Alcohol dehydrogenase [NADP(+)] P14550 Details Valacyclovir hydrolase Q86WA6 Details Acyl-coenzyme A thioesterase 13 Q9NPJ3 Details tRNA-splicing ligase RtcB homolog Q9Y3I0 Details Stromal cell-derived factor 2 Q99470 Details Epsin-1 Q9Y6I3 Details Superoxide dismutase [Mn], mitochondrial P04179 Details Phosphoglycerate kinase 1 P00558 Details Thiosulfate sulfurtransferase Q16762 Details Citrate synthase, mitochondrial O75390 Details Vimentin P08670 Details Cytochrome b5 type B O43169 Details Acyl-CoA-binding protein P07108 Details Adenylate kinase 2, mitochondrial P54819 Details NADPH:adrenodoxin oxidoreductase, mitochondrial P22570 Details Ras-related protein Rab-7a P51149 Details Galectin-1 P09382 Details Cation-dependent mannose-6-phosphate receptor P20645 Details Enoyl-CoA hydratase, mitochondrial P30084 Details Signal recognition particle 14 kDa protein P37108 Details Aconitate hydratase, mitochondrial Q99798 Details NADH-cytochrome b5 reductase 1 Q9UHQ9 Details Vesicle-fusing ATPase P46459 Details 3-ketoacyl-CoA thiolase, peroxisomal P09110 Details V-type proton ATPase subunit C 1 P21283 Details Isocitrate dehydrogenase [NADP], mitochondrial P48735 Details Fumarylacetoacetase P16930 Details Ras-related protein Rab-5A P20339 Details ADP-ribosylation factor-like protein 1 P40616 Details Palmitoyl-protein thioesterase 1 P50897 Details Elongation factor Tu, mitochondrial P49411 Details NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 Details T-complex protein 1 subunit gamma P49368 Details Ras-related protein Rab-11A P62491 Details GTP-binding nuclear protein Ran P62826 Details Ras-related protein Ral-A P11233 Details L-amino-acid oxidase Q96RQ9 Details Carboxypeptidase D O75976 Details 14-3-3 protein epsilon P62258 Details [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial O14874 Details Transitional endoplasmic reticulum ATPase P55072 Details Ubiquitin-like modifier-activating enzyme 1 P22314 Details Sorting nexin-3 O60493 Details Catechol O-methyltransferase domain-containing protein 1 Q86VU5 Details Spectrin beta chain, non-erythrocytic 1 Q01082 Details Cell division control protein 42 homolog P60953 Details Alpha-N-acetylgalactosaminidase P17050 Details Eukaryotic translation initiation factor 2 subunit 3 P41091 Details ADP-ribosylation factor-like protein 3 P36405 Details Thymidine kinase 2, mitochondrial O00142 Details Peroxiredoxin-6 P30041 Details Sodium bicarbonate cotransporter 3 Q9Y6M7 Details Neutral alpha-glucosidase AB Q14697 Details Proteasome subunit beta type-8 P28062 Details Adenylate kinase 4, mitochondrial P27144 Details Transferrin receptor protein 1 P02786 Details 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Q15125 Details Membrane-associated progesterone receptor component 1 O00264 Details Ras-related C3 botulinum toxin substrate 2 P15153 Details Complement component 1 Q subcomponent-binding protein, mitochondrial Q07021 Details Thioredoxin P10599 Details Actin, cytoplasmic 1 P60709 Details Actin, cytoplasmic 2 P63261 Details Sodium/potassium-transporting ATPase subunit beta-3 P54709 Details Histone H1.4 P10412 Details Chloride intracellular channel protein 1 O00299 Details Casein kinase II subunit beta P67870 Details ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 P28907 Details Dihydropyrimidinase-related protein 2 Q16555 Details Alpha-enolase P06733 Details Programmed cell death protein 6 O75340 Details Protein SCO1 homolog, mitochondrial O75880 Details Nucleolar and coiled-body phosphoprotein 1 Q14978 Details Utrophin P46939 Details Peroxiredoxin-1 Q06830 Details Apolipoprotein B receptor Q0VD83 Details Lysosomal protective protein P10619 Details Tricarboxylate transport protein, mitochondrial P53007 Details Calcium and integrin-binding protein 1 Q99828 Details Sorcin P30626 Details Calcineurin B homologous protein 1 Q99653 Details Translationally-controlled tumor protein P13693 Details Nucleobindin-2 P80303 Details Calmodulin-2 P0DP24 Details Calmodulin-3 P0DP25 Details 60 kDa heat shock protein, mitochondrial P10809 Details 40S ribosomal protein S2 P15880 Details Heterogeneous nuclear ribonucleoproteins A2/B1 P22626 Details Heterogeneous nuclear ribonucleoprotein H3 P31942 Details Heterogeneous nuclear ribonucleoprotein L P14866 Details Splicing factor, proline- and glutamine-rich P23246 Details Receptor of activated protein C kinase 1 P63244 Details Alpha-actinin-1 P12814 Details Stress-induced-phosphoprotein 1 P31948 Details Eukaryotic translation initiation factor 6 P56537 Details Eukaryotic initiation factor 4A-I P60842 Details 14-3-3 protein beta/alpha P31946 Details Proteasome activator complex subunit 1 Q06323 Details Phosphoglycerate mutase 1 P18669 Details Ran-specific GTPase-activating protein P43487 Details Protein disulfide-isomerase A3 P30101 Details Integrin alpha-5 P08648 Details Frataxin, mitochondrial Q16595 Details Cystatin-B P04080 Details Minor histocompatibility antigen H13 Q8TCT9 Details Prohibitin-2 Q99623 Details ATP synthase subunit a P00846 Details Eukaryotic translation initiation factor 3 subunit F O00303 Details RuvB-like 2 Q9Y230 Details ATP synthase subunit e, mitochondrial P56385 Details ATP synthase subunit g, mitochondrial O75964 Details Diablo homolog, mitochondrial Q9NR28 Details Heterogeneous nuclear ribonucleoprotein F P52597 Details Heterogeneous nuclear ribonucleoprotein K P61978 Details 10 kDa heat shock protein, mitochondrial P61604 Details Nuclear migration protein nudC Q9Y266 Details Protein S100-A10 P60903 Details Tumor protein D54 O43399 Details Tropomyosin alpha-3 chain P06753 Details 14-3-3 protein eta Q04917 Details 14-3-3 protein theta P27348 Details Proliferating cell nuclear antigen P12004 Details Keratin, type II cytoskeletal 1 P04264 Details Keratin, type I cytoskeletal 10 P13645 Details Keratin, type II cytoskeletal 2 epidermal P35908 Details Keratin, type I cytoskeletal 9 P35527 Details Dermcidin P81605 Details Keratin, type I cytoskeletal 14 P02533 Details Keratin, type I cytoskeletal 16 P08779 Details Keratin, type II cytoskeletal 5 P13647 Details Amyloid-like protein 2 Q06481 Details Far upstream element-binding protein 2 Q92945 Details ATP synthase subunit O, mitochondrial P48047 Details Cysteine and glycine-rich protein 1 P21291 Details Filamin-A P21333 Details Heterogeneous nuclear ribonucleoprotein D0 Q14103 Details Ras GTPase-activating-like protein IQGAP1 P46940 Details Nucleophosmin P06748 Details 60S ribosomal protein L10 P27635 Details 60S ribosomal protein L14 P50914 Details 60S ribosomal protein L18 Q07020 Details 60S ribosomal protein L35 P42766 Details 60S ribosomal protein L4 P36578 Details 40S ribosomal protein S13 P62277 Details 40S ribosomal protein S17 P08708 Details 40S ribosomal protein S18 P62269 Details 40S ribosomal protein S19 P39019 Details 40S ribosomal protein S28 P62857 Details 40S ribosomal protein S5 P46782 Details 40S ribosomal protein S6 P62753 Details 40S ribosomal protein S8 P62241 Details 40S ribosomal protein S9 P46781 Details Small nuclear ribonucleoprotein Sm D2 P62316 Details Transgelin-2 P37802 Details Zyxin Q15942 Details Serine/arginine-rich splicing factor 1 Q07955 Details Myosin-9 P35579 Details Probable ATP-dependent RNA helicase DDX5 P17844 Details Arylsulfatase B P15848 Details Elongation of very long chain fatty acids protein 5 Q9NYP7 Details Atypical kinase COQ8A, mitochondrial Q8NI60 Details Atypical kinase COQ8B, mitochondrial Q96D53 Details Epoxide hydrolase 1 P07099 Details Alpha-methylacyl-CoA racemase D6RB81 Details Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Q16822 Details Exportin-1 O14980 Details Prohibitin P35232 Details Hexokinase-2 P52789 Details Voltage-gated potassium channel subunit beta-2 Q13303 Details Zinc transporter 9 Q6PML9 Details Zinc transporter SLC39A7 Q92504 Details Serum paraoxonase/arylesterase 2 Q15165 Details Elongation of very long chain fatty acids protein 1 Q9BW60 Details V-type proton ATPase subunit d 1 P61421 Details Tyrosine-protein phosphatase non-receptor type 6 P29350 Details V-type proton ATPase 16 kDa proteolipid subunit P27449 Details V-type proton ATPase subunit D Q9Y5K8 Details V-type proton ATPase subunit F Q16864 Details V-type proton ATPase subunit E 1 P36543 Details V-type proton ATPase subunit G 1 O75348 Details Mitochondrial potassium channel Q96ER9 Details Plasma membrane calcium-transporting ATPase 4 P23634 Details Beta-galactosidase P16278 Details Leucyl-cystinyl aminopeptidase Q9UIQ6 Details 3-ketoacyl-CoA thiolase, mitochondrial P42765 Details HLA class I histocompatibility antigen, C alpha chain P10321 Details ELAV-like protein 1 Q15717 Details Apoptosis regulator BAX Q07812 Details Bcl-2-binding component 3, isoforms 1/2 Q9BXH1 Details IgG receptor FcRn large subunit p51 P55899 Details