N-terminome analysis of the human mitochondrial proteome.

Article Details

Citation

Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C

N-terminome analysis of the human mitochondrial proteome.

Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8.

PubMed ID
25944712 [ View in PubMed
]
Abstract

The high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the free N-terminome analysis of human mitochondria-enriched samples using trimethoxyphenyl phosphonium (TMPP) labelling approaches. Owing to the extent of protein import and cleavage for mitochondrial proteins, determining the new N-termini generated after translocation/processing events for mitochondrial proteins is crucial to understand the transformation of precursors to mature proteins. The doublet N-terminal oriented proteomics (dN-TOP) strategy based on a double light/heavy TMPP labelling has been optimized in order to improve and automate the workflow for efficient, fast and reliable high throughput N-terminome analysis. A total of 2714 proteins were identified and 897 N-terminal peptides were characterized (424 N-alpha-acetylated and 473 TMPP-labelled peptides). These results allowed the precise identification of the N-terminus of 693 unique proteins corresponding to 26% of all identified proteins. Overall, 120 already annotated processing cleavage sites were confirmed while 302 new cleavage sites were characterized. The accumulation of experimental evidence of mature N-termini should allow increasing the knowledge of processing mechanisms and consequently also enhance cleavage sites prediction algorithms. Complete datasets have been deposited to the ProteomeXchange Consortium with identifiers PXD001521, PXD001522 and PXD001523 (http://proteomecentral.proteomexchange.org/dataset/PXD001521, http://proteomecentral.proteomexchange.org/dataset/PXD0001522 and http://proteomecentral.proteomexchange.org/dataset/PXD001523, respectively).

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
NAD(P) transhydrogenase, mitochondrialQ13423Details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialP50213Details
Prostaglandin G/H synthase 1P23219Details
Phenylalanine--tRNA ligase, mitochondrialO95363Details
7-dehydrocholesterol reductaseQ9UBM7Details
Dehydrogenase/reductase SDR family member 4Q9BTZ2Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialO00217Details
Phenylalanine--tRNA ligase alpha subunitQ9Y285Details
TransketolaseP29401Details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingQ15738Details
High affinity immunoglobulin epsilon receptor subunit gammaP30273Details
Prolyl 4-hydroxylase subunit alpha-1P13674Details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialP10515Details
L-lactate dehydrogenase B chainP07195Details
Acetyl-CoA acetyltransferase, mitochondrialP24752Details
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialQ9HCC0Details
Hypoxanthine-guanine phosphoribosyltransferaseP00492Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialO95299Details
Ferritin light chainP02792Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Q02809Details
Pyruvate kinase PKMP14618Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5O43920Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialO75380Details
Mitochondrial basic amino acids transporterQ8N8R3Details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialP11177Details
Adenine phosphoribosyltransferaseP07741Details
3-hydroxyisobutyrate dehydrogenase, mitochondrialP31937Details
Hemoglobin subunit alphaP69905Details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialP19404Details
AFG3-like protein 2Q9Y4W6Details
Tubulin beta chainP07437Details
NAD-dependent malic enzyme, mitochondrialP23368Details
Cysteine desulfurase, mitochondrialQ9Y697Details
Sigma non-opioid intracellular receptor 1Q99720Details
NADH-cytochrome b5 reductase 3P00387Details
D-3-phosphoglycerate dehydrogenaseO43175Details
2-oxoglutarate dehydrogenase, mitochondrialQ02218Details
Cytochrome c oxidase subunit NDUFA4O00483Details
NADH dehydrogenase [ubiquinone] 1 subunit C2O95298Details
D-beta-hydroxybutyrate dehydrogenase, mitochondrialQ02338Details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialP31040Details
Carnitine O-palmitoyltransferase 2, mitochondrialP23786Details
Glutamate dehydrogenase 1, mitochondrialP00367Details
Bifunctional glutamate/proline--tRNA ligaseP07814Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialO75489Details
Lysine--tRNA ligaseQ15046Details
Mitochondrial ornithine transporter 1Q9Y619Details
Probable leucine--tRNA ligase, mitochondrialQ15031Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6P56556Details
Large neutral amino acids transporter small subunit 1Q01650Details
Valine--tRNA ligaseP26640Details
Pyrroline-5-carboxylate reductase 1, mitochondrialP32322Details
Tyrosine--tRNA ligase, cytoplasmicP54577Details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialQ02252Details
Calcium-binding mitochondrial carrier protein Aralar1O75746Details
Neutral amino acid transporter B(0)Q15758Details
Adrenodoxin, mitochondrialP10109Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialO43674Details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialP30038Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10O96000Details
Apoptosis regulator Bcl-2P10415Details
Purine nucleoside phosphorylaseP00491Details
Trifunctional enzyme subunit alpha, mitochondrialP40939Details
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialP13995Details
Calcium-binding mitochondrial carrier protein Aralar2Q9UJS0Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3O43676Details
4-trimethylaminobutyraldehyde dehydrogenaseP49189Details
HCG20471, isoform CRA_cQ5T1J1Details
Serine hydroxymethyltransferase, mitochondrialP34897Details
Alanine--tRNA ligase, cytoplasmicP49588Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4O95168Details
Sorbitol dehydrogenaseQ00796Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialQ16795Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialO75251Details
3-hydroxyacyl-CoA dehydrogenase type-2Q99714Details
Methylmalonic aciduria type A protein, mitochondrialQ8IVH4Details
Cytochrome c oxidase subunit 1P00395Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1O75438Details
Glycine amidinotransferase, mitochondrialP50440Details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialQ96I99Details
GDH/6PGL endoplasmic bifunctional proteinO95479Details
Tyrosine--tRNA ligase, mitochondrialQ9Y2Z4Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8P51970Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6O95139Details
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialQ16836Details
Dihydroorotate dehydrogenase (quinone), mitochondrialQ02127Details
Aspartate aminotransferase, mitochondrialP00505Details
Neutrophil elastaseP08246Details
Isovaleryl-CoA dehydrogenase, mitochondrialP26440Details
Ferritin heavy chainP02794Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7O95182Details
Carnitine O-palmitoyltransferase 1, liver isoformP50416Details
Peroxisomal multifunctional enzyme type 2P51659Details
CalmodulinP0DP23Details
Ornithine aminotransferase, mitochondrialP04181Details
L-lactate dehydrogenase A chainP00338Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialO95178Details
Serine palmitoyltransferase 1O15269Details
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialQ96RQ3Details
Monocarboxylate transporter 4O15427Details
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialQ96EY8Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Q16718Details
Aldehyde dehydrogenase X, mitochondrialP30837Details
Neutral amino acid transporter AP43007Details
ATP synthase subunit delta, mitochondrialP30049Details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialP49821Details
Isoleucine--tRNA ligase, cytoplasmicP41252Details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialP28331Details
Carnitine O-acetyltransferaseP43155Details
Low-density lipoprotein receptorP01130Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialO43181Details
NADH-ubiquinone oxidoreductase chain 1P03886Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7P17568Details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialO75600Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Q9P0J0Details
Serum albuminP02768Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11Q86Y39Details
Glyceraldehyde-3-phosphate dehydrogenaseP04406Details
Acyl carrier protein, mitochondrialO14561Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2O43678Details
NADH-ubiquinone oxidoreductase chain 4P03905Details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialO43837Details
Phenylalanine--tRNA ligase beta subunitQ9NSD9Details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialP08559Details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialP45954Details
Squalene monooxygenaseQ14534Details
Mitochondrial carnitine/acylcarnitine carrier proteinO43772Details
NADH-ubiquinone oxidoreductase chain 5P03915Details
Heme oxygenase 2P30519Details
Malate dehydrogenase, cytoplasmicP40925Details
Integrin alpha-4P13612Details
Retinol dehydrogenase 13Q8NBN7Details
Flavin reductase (NADPH)P30043Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Q9Y6M9Details
ADP/ATP translocase 1P12235Details
Asparagine--tRNA ligase, cytoplasmicO43776Details
C-1-tetrahydrofolate synthase, cytoplasmicP11586Details
ADP/ATP translocase 3P12236Details
Long-chain-fatty-acid--CoA ligase 1P33121Details
Glutathione reductase, mitochondrialP00390Details
NADH-ubiquinone oxidoreductase chain 2P03891Details
Monocarboxylate transporter 1P53985Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3O95167Details
Pyruvate carboxylase, mitochondrialP11498Details
ADP/ATP translocase 2P05141Details
Branched-chain-amino-acid aminotransferase, mitochondrialO15382Details
Inosine-5'-monophosphate dehydrogenase 2P12268Details
Aspartate--tRNA ligase, cytoplasmicP14868Details
Pyrroline-5-carboxylate reductase 2Q96C36Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialO75306Details
Mitochondrial folate transporter/carrierQ9H2D1Details
Sodium/potassium-transporting ATPase subunit alpha-1P05023Details
Translocator proteinP30536Details
Dihydrolipoyl dehydrogenase, mitochondrialP09622Details
Biliverdin reductase AP53004Details
Acetyl-coenzyme A synthetase 2-like, mitochondrialQ9NUB1Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Q9UI09Details
Short-chain specific acyl-CoA dehydrogenase, mitochondrialP16219Details
Leucine--tRNA ligase, cytoplasmicQ9P2J5Details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialP51553Details
Farnesyl pyrophosphate synthaseP14324Details
Methylmalonyl-CoA mutase, mitochondrialP22033Details
Malate dehydrogenase, mitochondrialP40926Details
Glutathione S-transferase kappa 1Q9Y2Q3Details
Glutathione S-transferase PP09211Details
Glutathione S-transferase omega-1P78417Details
Glutathione peroxidase 1P07203Details
Delta-1-pyrroline-5-carboxylate synthaseP54886Details
Glutaminase kidney isoform, mitochondrialO94925Details
Perilipin-3O60664Details
L-xylulose reductaseQ7Z4W1Details
Lanosterol 14-alpha demethylaseQ16850Details
Lysosomal alpha-glucosidaseP10253Details
N-acetylgalactosamine-6-sulfataseP34059Details
Peroxiredoxin-5, mitochondrialP30044Details
Eosinophil cationic proteinP12724Details
Growth factor receptor-bound protein 2P62993Details
Sulfotransferase 1A1P50225Details
Cytochrome bP00156Details
Cathepsin BP07858Details
Cathepsin DP07339Details
Alpha-1-antitrypsinP01009Details
MyeloblastinP24158Details
Phosphatidylinositol 3-kinase regulatory subunit alphaP27986Details
Fatty acid synthaseP49327Details
Lactoylglutathione lyaseQ04760Details
Apoptosis-inducing factor 1, mitochondrialO95831Details
Beta-glucuronidaseP08236Details
Transforming growth factor beta-1P01137Details
Protein deglycase DJ-1Q99497Details
Long-chain-fatty-acid--CoA ligase 4O60488Details
Glycine--tRNA ligaseP41250Details
Cytochrome b-c1 complex subunit 1, mitochondrialP31930Details
Cytochrome cP99999Details
Cathepsin GP08311Details
CalnexinP27824Details
Peptidyl-prolyl cis-trans isomerase AP62937Details
Mitogen-activated protein kinase 14Q16539Details
Ferrochelatase, mitochondrialP22830Details
Integrin beta-2P05107Details
Choline transporter-like protein 1Q8WWI5Details
VitronectinP04004Details
Aminopeptidase NP15144Details
Cyclin-dependent kinase 1P06493Details
Intercellular adhesion molecule 1P05362Details
Long-chain-fatty-acid--CoA ligase 3O95573Details
78 kDa glucose-regulated proteinP11021Details
Phosphatidylserine synthase 1P48651Details
Hexokinase-1P19367Details
Ras-related C3 botulinum toxin substrate 1P63000Details
CD44 antigenP16070Details
Heat shock protein HSP 90-alphaP07900Details
Phospholipid hydroperoxide glutathione peroxidase, mitochondrialP36969Details
Protein-L-isoaspartate(D-aspartate) O-methyltransferaseP22061Details
Beta-hexosaminidase subunit betaP07686Details
Inhibitor of nuclear factor kappa-B kinase subunit betaO14920Details
Endothelial protein C receptorQ9UNN8Details
EndoplasminP14625Details
Annexin A2P07355Details
Cytochrome b5P00167Details
14-3-3 protein zeta/deltaP63104Details
ProsaposinP07602Details
Phosphatidylethanolamine-binding protein 1P30086Details
Quinone oxidoreductaseQ08257Details
Transforming protein RhoAP61586Details
Glucose-6-phosphate isomeraseP06744Details
Equilibrative nucleoside transporter 1Q99808Details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialP33316Details
CatalaseP04040Details
Thymidylate kinaseP23919Details
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Q10588Details
Isocitrate dehydrogenase [NADP] cytoplasmicO75874Details
Tubulin alpha-1B chainP68363Details
Tyrosine-protein kinase BTKQ06187Details
Non-secretory ribonucleaseP10153Details
Acetyl-CoA acetyltransferase, cytosolicQ9BWD1Details
Galectin-3P17931Details
Tubulin beta-4B chainP68371Details
Tubulin alpha-4A chainP68366Details
Peptidyl-prolyl cis-trans isomerase F, mitochondrialP30405Details
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseQ9UKM7Details
Tyrosine-protein kinase HCKP08631Details
Ganglioside GM2 activatorP17900Details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitP36873Details
Lanosterol synthaseP48449Details
Tryptase beta-2P20231Details
Coatomer subunit gamma-1Q9Y678Details
Cathepsin SP25774Details
Ribonuclease UK114P52758Details
Fructose-bisphosphate aldolase AP04075Details
Ras-related protein Rab-9AP51151Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialP11310Details
Enoyl-CoA delta isomerase 1, mitochondrialP42126Details
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3Q96T66Details
Macrophage migration inhibitory factorP14174Details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3O94766Details
Thromboxane-A synthaseP24557Details
Heat shock protein HSP 90-betaP08238Details
Cathepsin L2O60911Details
Glutaryl-CoA dehydrogenase, mitochondrialQ92947Details
Peroxiredoxin-2P32119Details
Fatty acid-binding protein, epidermalQ01469Details
Catechol O-methyltransferaseP21964Details
CalreticulinP27797Details
Phytanoyl-CoA dioxygenase, peroxisomalO14832Details
Protein ERGIC-53P49257Details
Multiple coagulation factor deficiency protein 2Q8NI22Details
Proline synthase co-transcribed bacterial homolog proteinO94903Details
Phospholipase D1Q13393Details
Choline transporter-like protein 2Q8IWA5Details
Choline/ethanolaminephosphotransferase 1Q9Y6K0Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3O60568Details
Peptide deformylase, mitochondrialQ9HBH1Details
Prolyl 3-hydroxylase 1Q32P28Details
Aspartate--tRNA ligase, mitochondrialQ6PI48Details
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrialO75879Details
Fatty acid desaturase 2O95864Details
Methionine--tRNA ligase, mitochondrialQ96GW9Details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialO14521Details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialP21912Details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialP53597Details
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialP55809Details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialQ99643Details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialQ9P2R7Details
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidaseQ9UK23Details
Probable glutamate--tRNA ligase, mitochondrialQ5JPH6Details
Mitochondrial glutamate carrier 1Q9H936Details
Microsomal glutathione S-transferase 3O14880Details
Thioredoxin domain-containing protein 12O95881Details
Microsomal glutathione S-transferase 1P10620Details
S-formylglutathione hydrolaseP10768Details
Glutaredoxin-1P35754Details
Microsomal glutathione S-transferase 2Q99735Details
Glycine cleavage system H protein, mitochondrialP23434Details
Tryptophan--tRNA ligase, mitochondrialQ9UGM6Details
Probable cysteine--tRNA ligase, mitochondrialQ9HA77Details
Threonine--tRNA ligase, mitochondrialQ9BW92Details
Alanine--tRNA ligase, mitochondrialQ5JTZ9Details
Retinol dehydrogenase 11Q8TC12Details
Retinol dehydrogenase 14Q9HBH5Details
Isoleucine--tRNA ligase, mitochondrialQ9NSE4Details
Vitamin K epoxide reductase complex subunit 1-like protein 1Q8N0U8Details
Peptidyl-prolyl cis-trans isomerase HO43447Details
Peptidyl-prolyl cis-trans isomerase BP23284Details
Probable asparagine--tRNA ligase, mitochondrialQ96I59Details
Proteasome subunit beta type-1P20618Details
Proteasome subunit beta type-2P49721Details
Guanylate kinaseQ16774Details
NADPH--cytochrome P450 reductaseP16435Details
Arachidonate 5-lipoxygenase-activating proteinP20292Details
Phosphatidylinositol 3-kinase regulatory subunit betaO00459Details
DNA-dependent protein kinase catalytic subunitP78527Details
Serine/threonine-protein kinase mTORP42345Details
Superoxide dismutase [Cu-Zn]P00441Details
40S ribosomal protein SAP08865Details
Disintegrin and metalloproteinase domain-containing protein 10O14672Details
DNA-(apurinic or apyrimidinic site) lyaseP27695Details
Alpha-galactosidase AP06280Details
Squalene synthaseP37268Details
Protein disulfide-isomeraseP07237Details
Voltage-dependent anion-selective channel protein 1P21796Details
Voltage-dependent anion-selective channel protein 2P45880Details
Voltage-dependent anion-selective channel protein 3Q9Y277Details
Oxidoreductase HTATIP2Q9BUP3Details
Prostaglandin E synthase 3Q15185Details
Probable ATP-dependent RNA helicase DDX6P26196Details
Wiskott-Aldrich syndrome proteinP42768Details
Liver carboxylesterase 1P23141Details
ATP-dependent Clp protease proteolytic subunit, mitochondrialQ16740Details
Protein S100-A11P31949Details
Ig gamma-1 chain C regionP01857Details
Protein S100-A6P06703Details
Nucleoside diphosphate kinase AP15531Details
Antigen peptide transporter 1Q03518Details
2,4-dienoyl-CoA reductase, mitochondrialQ16698Details
Golgi-associated plant pathogenesis-related protein 1Q9H4G4Details
Trafficking protein particle complex subunit 3O43617Details
ADP-ribosylation factor 4P18085Details
Nucleoside diphosphate kinase BP22392Details
GalactokinaseP51570Details
Hydroxymethylglutaryl-CoA lyase, mitochondrialP35914Details
Cytochrome c oxidase subunit 2P00403Details
Thioredoxin reductase 2, mitochondrialQ9NNW7Details
cAMP-dependent protein kinase type II-alpha regulatory subunitP13861Details
High mobility group protein B1P09429Details
Heat shock protein beta-1P04792Details
Ribosome-binding protein 1Q9P2E9Details
Transmembrane glycoprotein NMBQ14956Details
Microtubule-associated protein 4P27816Details
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2P16615Details
HLA class I histocompatibility antigen, A-3 alpha chainP04439Details
Alpha-mannosidase 2Q16706Details
Bcl-2-like protein 1Q07817Details
V-type proton ATPase catalytic subunit AP38606Details
Integrin beta-1P05556Details
Cation-independent mannose-6-phosphate receptorP11717Details
ATP-binding cassette sub-family B member 8, mitochondrialQ9NUT2Details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortP63092Details
Tryptase alpha/beta-1Q15661Details
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformP30153Details
Lysozyme CP61626Details
cAMP-dependent protein kinase catalytic subunit alphaP17612Details
S-phase kinase-associated protein 1P63208Details
Heat shock cognate 71 kDa proteinP11142Details
Beta-2-microglobulinP61769Details
Low molecular weight phosphotyrosine protein phosphataseP24666Details
Dual specificity protein phosphatase 23Q9BVJ7Details
Endothelin-converting enzyme 1P42892Details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunitP62136Details
Malonyl-CoA-acyl carrier protein transacylase, mitochondrialQ8IVS2Details
V-type proton ATPase subunit B, brain isoformP21281Details
ADP-ribosylation factor 1P84077Details
60S ribosomal protein L13aP40429Details
60S ribosomal protein L23P62829Details
60S ribosomal protein L15P61313Details
60S ribosomal protein L19P84098Details
60S ribosomal protein L23aP62750Details
60S ribosomal protein L8P62917Details
60S ribosomal protein L3P39023Details
60S ribosomal protein L11P62913Details
NHP2-like protein 1P55769Details
ATP synthase subunit alpha, mitochondrialP25705Details
ATP synthase subunit beta, mitochondrialP06576Details
ATP synthase subunit gamma, mitochondrialP36542Details
Triosephosphate isomeraseP60174Details
Cytochrome c1, heme protein, mitochondrialP08574Details
Cytochrome b-c1 complex subunit 2, mitochondrialP22695Details
Cytochrome b-c1 complex subunit 6, mitochondrialP07919Details
Cytochrome b-c1 complex subunit 8O14949Details
Cytochrome b-c1 complex subunit Rieske, mitochondrialP47985Details
Cytochrome b-c1 complex subunit 7P14927Details
Cytochrome b-c1 complex subunit 9Q9UDW1Details
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialQ15118Details
Cytosol aminopeptidaseP28838Details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialQ16134Details
Proteasome subunit alpha type-1P25786Details
Proteasome subunit alpha type-2P25787Details
Proteasome subunit alpha type-7O14818Details
Proteasome subunit beta type-4P28070Details
Retinoid-inducible serine carboxypeptidaseQ9HB40Details
Pro-cathepsin HP09668Details
Cytochrome c oxidase subunit 4 isoform 1, mitochondrialP13073Details
Cytochrome c oxidase subunit 3P00414Details
Cytochrome c oxidase subunit 5A, mitochondrialP20674Details
Cytochrome c oxidase subunit 5B, mitochondrialP10606Details
Cytochrome c oxidase subunit 6CP09669Details
Cytochrome c oxidase subunit 7C, mitochondrialP15954Details
Cytochrome c oxidase subunit 6B1P14854Details
Isopentenyl-diphosphate Delta-isomerase 1Q13907Details
GTPase KRasP01116Details
HLA class I histocompatibility antigen, B-27 alpha chainP01889Details
Platelet-activating factor acetylhydrolase IB subunit gammaQ15102Details
Serine/threonine-protein kinase 26Q9P289Details
Methionine aminopeptidase 1P53582Details
Profilin-1P07737Details
Peroxisomal acyl-coenzyme A oxidase 1Q15067Details
Calpain small subunit 1P04632Details
Annexin A5P08758Details
DestrinP60981Details
Cofilin-1P23528Details
Rho-associated protein kinase 2O75116Details
Enoyl-CoA delta isomerase 2, mitochondrialO75521Details
ADP-ribosylation factor 6P62330Details
Poliovirus receptorP15151Details
Actin-related protein 2/3 complex subunit 1BO15143Details
Actin-related protein 2P61160Details
Actin-related protein 3P61158Details
Actin-related protein 2/3 complex subunit 2O15144Details
Actin-related protein 2/3 complex subunit 3O15145Details
Actin-related protein 2/3 complex subunit 5O15511Details
Elongation factor 2P13639Details
Tyrosine-protein kinase LynP07948Details
3-hydroxyisobutyryl-CoA hydrolase, mitochondrialQ6NVY1Details
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrialQ15120Details
Protein S100-A4P26447Details
Alcohol dehydrogenase [NADP(+)]P14550Details
Valacyclovir hydrolaseQ86WA6Details
Acyl-coenzyme A thioesterase 13Q9NPJ3Details
tRNA-splicing ligase RtcB homologQ9Y3I0Details
Stromal cell-derived factor 2Q99470Details
Epsin-1Q9Y6I3Details
Superoxide dismutase [Mn], mitochondrialP04179Details
Phosphoglycerate kinase 1P00558Details
Thiosulfate sulfurtransferaseQ16762Details
Citrate synthase, mitochondrialO75390Details
VimentinP08670Details
Cytochrome b5 type BO43169Details
Acyl-CoA-binding proteinP07108Details
Adenylate kinase 2, mitochondrialP54819Details
NADPH:adrenodoxin oxidoreductase, mitochondrialP22570Details
Ras-related protein Rab-7aP51149Details
Galectin-1P09382Details
Cation-dependent mannose-6-phosphate receptorP20645Details
Enoyl-CoA hydratase, mitochondrialP30084Details
Signal recognition particle 14 kDa proteinP37108Details
Aconitate hydratase, mitochondrialQ99798Details
NADH-cytochrome b5 reductase 1Q9UHQ9Details
Vesicle-fusing ATPaseP46459Details
3-ketoacyl-CoA thiolase, peroxisomalP09110Details
V-type proton ATPase subunit C 1P21283Details
Isocitrate dehydrogenase [NADP], mitochondrialP48735Details
FumarylacetoacetaseP16930Details
Ras-related protein Rab-5AP20339Details
ADP-ribosylation factor-like protein 1P40616Details
Palmitoyl-protein thioesterase 1P50897Details
Elongation factor Tu, mitochondrialP49411Details
NAD-dependent protein deacetylase sirtuin-3, mitochondrialQ9NTG7Details
T-complex protein 1 subunit gammaP49368Details
Ras-related protein Rab-11AP62491Details
GTP-binding nuclear protein RanP62826Details
Ras-related protein Ral-AP11233Details
L-amino-acid oxidaseQ96RQ9Details
Carboxypeptidase DO75976Details
14-3-3 protein epsilonP62258Details
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialO14874Details
Transitional endoplasmic reticulum ATPaseP55072Details
Ubiquitin-like modifier-activating enzyme 1P22314Details
Sorting nexin-3O60493Details
Catechol O-methyltransferase domain-containing protein 1Q86VU5Details
Spectrin beta chain, non-erythrocytic 1Q01082Details
Cell division control protein 42 homologP60953Details
Alpha-N-acetylgalactosaminidaseP17050Details
Eukaryotic translation initiation factor 2 subunit 3P41091Details
ADP-ribosylation factor-like protein 3P36405Details
Thymidine kinase 2, mitochondrialO00142Details
Peroxiredoxin-6P30041Details
Sodium bicarbonate cotransporter 3Q9Y6M7Details
Neutral alpha-glucosidase ABQ14697Details
Proteasome subunit beta type-8P28062Details
Adenylate kinase 4, mitochondrialP27144Details
Transferrin receptor protein 1P02786Details
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseQ15125Details
Membrane-associated progesterone receptor component 1O00264Details
Ras-related C3 botulinum toxin substrate 2P15153Details
Complement component 1 Q subcomponent-binding protein, mitochondrialQ07021Details
ThioredoxinP10599Details
Actin, cytoplasmic 1P60709Details
Actin, cytoplasmic 2P63261Details
Sodium/potassium-transporting ATPase subunit beta-3P54709Details
Histone H1.4P10412Details
Chloride intracellular channel protein 1O00299Details
Casein kinase II subunit betaP67870Details
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1P28907Details
Dihydropyrimidinase-related protein 2Q16555Details
Alpha-enolaseP06733Details
Programmed cell death protein 6O75340Details
Protein SCO1 homolog, mitochondrialO75880Details
Nucleolar and coiled-body phosphoprotein 1Q14978Details
UtrophinP46939Details
Peroxiredoxin-1Q06830Details
Apolipoprotein B receptorQ0VD83Details
Lysosomal protective proteinP10619Details
Tricarboxylate transport protein, mitochondrialP53007Details
Calcium and integrin-binding protein 1Q99828Details
SorcinP30626Details
Calcineurin B homologous protein 1Q99653Details
Translationally-controlled tumor proteinP13693Details
Nucleobindin-2P80303Details
Calmodulin-2P0DP24Details
Calmodulin-3P0DP25Details
60 kDa heat shock protein, mitochondrialP10809Details
40S ribosomal protein S2P15880Details
Heterogeneous nuclear ribonucleoproteins A2/B1P22626Details
Heterogeneous nuclear ribonucleoprotein H3P31942Details
Heterogeneous nuclear ribonucleoprotein LP14866Details
Splicing factor, proline- and glutamine-richP23246Details
Receptor of activated protein C kinase 1P63244Details
Alpha-actinin-1P12814Details
Stress-induced-phosphoprotein 1P31948Details
Eukaryotic translation initiation factor 6P56537Details
Eukaryotic initiation factor 4A-IP60842Details
14-3-3 protein beta/alphaP31946Details
Proteasome activator complex subunit 1Q06323Details
Phosphoglycerate mutase 1P18669Details
Ran-specific GTPase-activating proteinP43487Details
Protein disulfide-isomerase A3P30101Details
Integrin alpha-5P08648Details
Frataxin, mitochondrialQ16595Details
Cystatin-BP04080Details
Minor histocompatibility antigen H13Q8TCT9Details
Prohibitin-2Q99623Details
ATP synthase subunit aP00846Details
Eukaryotic translation initiation factor 3 subunit FO00303Details
RuvB-like 2Q9Y230Details
ATP synthase subunit e, mitochondrialP56385Details
ATP synthase subunit g, mitochondrialO75964Details
Diablo homolog, mitochondrialQ9NR28Details
Heterogeneous nuclear ribonucleoprotein FP52597Details
Heterogeneous nuclear ribonucleoprotein KP61978Details
10 kDa heat shock protein, mitochondrialP61604Details
Nuclear migration protein nudCQ9Y266Details
Protein S100-A10P60903Details
Tumor protein D54O43399Details
Tropomyosin alpha-3 chainP06753Details
14-3-3 protein etaQ04917Details
14-3-3 protein thetaP27348Details
Proliferating cell nuclear antigenP12004Details
Keratin, type II cytoskeletal 1P04264Details
Keratin, type I cytoskeletal 10P13645Details
Keratin, type II cytoskeletal 2 epidermalP35908Details
Keratin, type I cytoskeletal 9P35527Details
DermcidinP81605Details
Keratin, type I cytoskeletal 14P02533Details
Keratin, type I cytoskeletal 16P08779Details
Keratin, type II cytoskeletal 5P13647Details
Amyloid-like protein 2Q06481Details
Far upstream element-binding protein 2Q92945Details
ATP synthase subunit O, mitochondrialP48047Details
Cysteine and glycine-rich protein 1P21291Details
Filamin-AP21333Details
Heterogeneous nuclear ribonucleoprotein D0Q14103Details
Ras GTPase-activating-like protein IQGAP1P46940Details
NucleophosminP06748Details
60S ribosomal protein L10P27635Details
60S ribosomal protein L14P50914Details
60S ribosomal protein L18Q07020Details
60S ribosomal protein L35P42766Details
60S ribosomal protein L4P36578Details
40S ribosomal protein S13P62277Details
40S ribosomal protein S17P08708Details
40S ribosomal protein S18P62269Details
40S ribosomal protein S19P39019Details
40S ribosomal protein S28P62857Details
40S ribosomal protein S5P46782Details
40S ribosomal protein S6P62753Details
40S ribosomal protein S8P62241Details
40S ribosomal protein S9P46781Details
Small nuclear ribonucleoprotein Sm D2P62316Details
Transgelin-2P37802Details
ZyxinQ15942Details
Serine/arginine-rich splicing factor 1Q07955Details
Myosin-9P35579Details
Probable ATP-dependent RNA helicase DDX5P17844Details
Arylsulfatase BP15848Details
Elongation of very long chain fatty acids protein 5Q9NYP7Details
Atypical kinase COQ8A, mitochondrialQ8NI60Details
Atypical kinase COQ8B, mitochondrialQ96D53Details
Epoxide hydrolase 1P07099Details
Alpha-methylacyl-CoA racemaseD6RB81Details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialQ16822Details
Exportin-1O14980Details
ProhibitinP35232Details
Hexokinase-2P52789Details
Voltage-gated potassium channel subunit beta-2Q13303Details
Zinc transporter 9Q6PML9Details
Zinc transporter SLC39A7Q92504Details
Serum paraoxonase/arylesterase 2Q15165Details
Elongation of very long chain fatty acids protein 1Q9BW60Details
V-type proton ATPase subunit d 1P61421Details
Tyrosine-protein phosphatase non-receptor type 6P29350Details
V-type proton ATPase 16 kDa proteolipid subunitP27449Details
V-type proton ATPase subunit DQ9Y5K8Details
V-type proton ATPase subunit FQ16864Details
V-type proton ATPase subunit E 1P36543Details
V-type proton ATPase subunit G 1O75348Details
Mitochondrial potassium channelQ96ER9Details
Plasma membrane calcium-transporting ATPase 4P23634Details
Beta-galactosidaseP16278Details
Leucyl-cystinyl aminopeptidaseQ9UIQ6Details
3-ketoacyl-CoA thiolase, mitochondrialP42765Details
HLA class I histocompatibility antigen, C alpha chainP10321Details
ELAV-like protein 1Q15717Details
Apoptosis regulator BAXQ07812Details
Bcl-2-binding component 3, isoforms 1/2Q9BXH1Details
IgG receptor FcRn large subunit p51P55899Details