Holliday junction branch migration complex subunit RuvB

BE0001514ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)ruvB

The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). It is acted on by 1 drug in DrugBank.

Gene name
ruvB
UniProtKB entry
Q56313Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
334 residues · 37,156 Da
Also known as
3.6.4.- · 3.6.4.12 · Holliday junction ATP-dependent DNA helicase RuvB

Resolves to

Protein
UniProtQ56313UniProt nameRUVB_THEMA
Gene
NCBI Gene897204GenBank1063668
Pharmacology
KEGGtma:TM1730
Structure
PDB1IN4PDB1IN5PDB1IN6
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Holliday junction branch migration complex subunit RuvB, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In