Methionine aminopeptidase 2

BE0001534ProteinHumansMETAP2

Cotranslationally removes the N-terminal methionine from nascent proteins. It is acted on by 22 drugs in DrugBank.

Gene name
METAP2
UniProtKB entry
P50579Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
478 residues · 52,891 Da
Also known as
3.4.11.18 · Initiation factor 2-associated 67 kDa glycoprotein · MAP 2 · MetAP 2 · MNPEP

Resolves to

Protein
UniProtP50579UniProt nameMAP2_HUMAN
Gene
HGNCHGNC:16672NCBI Gene10988GenBank903982GeneCardsMETAP2
Pharmacology
IUPHAR/GtoPdb1573KEGGhsa:10988
Structure
PDB1B59PDB1B6APDB1BN5
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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77+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methionine aminopeptidase 2, how selective are they, and which programs against it are still in active trials?

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